Cui Lele, Chen Sisi, Zhou Weihe, Sheng Kaixuan, Zhang Lei, Shen Meixiao, Li Ming
Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Ningbo Aier Guangming Eye Hosptial, Ningbo, Zhejiang, China.
J Ophthalmol. 2018 May 13;2018:3463595. doi: 10.1155/2018/3463595. eCollection 2018.
To determine conjunctival overlap over the edge of soft contact lens and to visualize the peripheral postlens tear film (PoLTF) underneath soft contact lenses using ultrahigh-resolution optical coherence tomography (UHR-OCT).
Twenty participants (4 males and 16 females, 23.0 ± 3.7 years) were fitted with two different types of soft contact lenses randomly. The limbus with lens was imaged with the UHR-OCT at the horizontal meridian every two hours up to 6 hours during lens wear. The conjunctival overlap was ranked as the percentage of the edge covered by the conjunctiva. The frequency of occurrence for visualized peripheral PoLTF was determined.
The average conjunctival overlaps at insertion were 49% and 73% for galyfilcon A and balafilcon A lenses and increased significantly to 84% and 90% by 6 hours of lens wear ( < 0.001). Lenses with rounded edges had more conjunctival overlap than the lenses with angled edges (=0.014). There were significant decreases for PoLTF on the conjunctiva (=0.014) and peripheral cornea (=0.004) over the study period compared to insertion. The percentage of subjects with PoLTF on the conjunctiva (32.5%) and peripheral cornea (36%) were greater in subjects wearing balafilcon A lenses (=0.017).
Increased conjunctival overlap over the lens edges and reduced PoLTF underneath the peripheral region of soft contact lenses were shown during lens daily wear. The lens edge configuration may play a role in conjunctival response and peripheral PoLTF.
使用超高分辨率光学相干断层扫描（UHR-OCT）确定软性接触镜边缘上方的结膜覆盖情况，并观察软性接触镜下方的周边镜片后泪膜（PoLTF）。
20名参与者（4名男性和16名女性，23.0±3.7岁）随机佩戴两种不同类型的软性接触镜。在佩戴镜片期间，每两小时使用UHR-OCT在水平子午线上对佩戴镜片的角膜缘进行成像，直至6小时。结膜覆盖情况按结膜覆盖边缘的百分比进行分级。确定可视化周边PoLTF的出现频率。
加雷菲康A和巴拉菲康A镜片在插入时的平均结膜覆盖率分别为49%和73%，佩戴镜片6小时后显著增加至84%和90%（<0.001）。边缘呈圆形的镜片比边缘呈角形的镜片有更多的结膜覆盖（=0.014）。与插入时相比，在研究期间结膜（=0.014）和周边角膜（=0.004）上的PoLTF显著减少。佩戴巴拉菲康A镜片的受试者结膜（32.5%）和周边角膜（36%）出现PoLTF的受试者百分比更高（=0.017）。
在日常佩戴镜片期间，显示出镜片边缘上方结膜覆盖增加，软性接触镜周边区域下方的PoLTF减少。镜片边缘形态可能在结膜反应和周边PoLTF中起作用。
