Rodrigue James R, Baz Maher A, Widows Michelle R, Ehlers Shawna L
Center for Behavioral Health Research in Organ Transplantation and Donation, University of Florida, Gainesville, Florida, USA.
Am J Transplant. 2005 Oct;5(10):2425-32. doi: 10.1111/j.1600-6143.2005.01038.x.
Research shows that patients wait-listed for lung transplantation have very poor quality of life (QOL). This study evaluated the effectiveness of Quality-of-Life Therapy (QOLT) in improving QOL, mood disturbance and social intimacy in adults awaiting lung transplantation. Thirty-five adults were randomized to QOLT (n = 17) or supportive therapy (ST; n = 18) and received individual, telephone-based treatment sessions. QOL, mood and social intimacy assessments were conducted at baseline and at 1 and 3 months after treatment. Repeated measures analyses of variance showed significant Condition x Time interaction effects for all three primary outcome measures. Subsequent post hoc analyses showed that the two groups did not differ significantly at baseline, but did differ significantly at the 1- and 3-month follow-up assessments. When compared to ST patients, QOLT patients had significantly higher QOL scores at the 1- and 3-month assessments, lower mood disturbance scores at the 3-month assessment, and higher social intimacy scores at the 1-month assessment. Results indicate that a patient's QOL, mood state and relationship with the primary caregiver can be positively impacted by a brief psychological intervention prior to lung transplantation.
研究表明，等待肺移植的患者生活质量（QOL）非常差。本研究评估了生活质量疗法（QOLT）在改善等待肺移植的成年人的生活质量、情绪障碍和社会亲密度方面的有效性。35名成年人被随机分为QOLT组（n = 17）或支持性疗法（ST；n = 18），并接受基于电话的个体治疗课程。在基线以及治疗后1个月和3个月进行生活质量、情绪和社会亲密度评估。重复测量方差分析显示，所有三项主要结局指标均存在显著的条件×时间交互效应。随后的事后分析表明，两组在基线时无显著差异，但在1个月和3个月的随访评估中存在显著差异。与ST组患者相比，QOLT组患者在1个月和3个月评估时的生活质量得分显著更高，在3个月评估时的情绪障碍得分更低，在1个月评估时的社会亲密度得分更高。结果表明，在肺移植前进行简短的心理干预可以对患者的生活质量、情绪状态以及与主要照顾者的关系产生积极影响。
