Chen L, Hou Y, Jin Z, Wu J, Li Y, Gou Q, Xu P
Institute of Forensic Medicine, West China University of Medical Sciences, Chengdu, 610041 R.P. China.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 1998 Feb 10;15(1):13-6.
To understand the distribution of allele frequencies of blood factor XIIIB subunit(FXIIIB) in Chinese populations and evaluate the genetic polymorphism of FXIIIB for the purposes of population genetics and forensic haemogenetics.
The genetic polymorphism of FXIIIB subunit in seven Chinese populations was investigated. Isoelectrofocusing technique on polyoacrylamid gels followed by immunoblotting was used to determine the phenotype of individuals in each population sample.
There were three common alleles in all the seven Chinese populations. The frequency of FXIIIB3 was the highest, that of FXIIIB2 was the lowest, and the one of FXXIIIB*1 was at the middle. All of them reached to the polymorphism's level. A rare variant allele was also found in some Chinese populations. Comparison of the constituents of FXIIIB phenotypes in the seven populations showed that there was no significant difference (P>0.05). The distribution of the allele frequencies in these populations reflected most likely the mode of the distribution in all Chinese populations. The phylogenetic tree and genetic distance, based on the allele frequencies of FXIIIB differentiated the populations in the world into the main ethnic groups as what other authors reported.
FXIIIB is a useful genetic marker for population genetics and forensic haemogenetics.
了解中国人群中凝血因子ⅩⅢB亚基（FXIIIB）等位基因频率的分布情况，评估FXIIIB的基因多态性，为群体遗传学和法医血液遗传学研究提供依据。
对7个中国人群的FXIIIB亚基基因多态性进行调查。采用聚丙烯酰胺凝胶等电聚焦技术结合免疫印迹法确定各群体样本中个体的表型。
7个中国人群中均存在3种常见等位基因。FXIIIB3的频率最高，FXIIIB2的频率最低，FXIIIB*1的频率居中。三者均达到多态性水平。在部分中国人群中还发现了1个罕见的变异等位基因。7个群体中FXIIIB表型构成的比较显示差异无统计学意义（P>0.05）。这些人群中等位基因频率的分布很可能反映了全体中国人群的分布模式。基于FXIIIB等位基因频率构建的系统发育树和遗传距离，将世界各人群区分为主要种族群体，与其他作者的报道一致。
FXIIIB是群体遗传学和法医血液遗传学研究中有价值的遗传标记。
