LaBresh K A, Lally E V, Sharma S C, Ho G
Am J Med. 1985 Jun;78(6 Pt 1):908-12. doi: 10.1016/0002-9343(85)90211-6.
Two-dimensional echocardiographic findings of subaortic fibrous ridging, aortic leaflet thickening, and aortic root dilatation and thickening are described in a group of 36 patients with rheumatoid variant diseases. The group consisted of 25 patients with ankylosing spondylitis, nine patients with Reiter's syndrome, and two patients with inflammatory bowel disease and spondylitis. No patient had clinical or laboratory evidence of aortic regurgitation or heart block. Subaortic fibrous ridging or marked leaflet thickening was noted in 11 of 36 patients; in contrast, no such changes were found in an age-matched control group of 29 men. The subgroup of patients with subaortic fibrous ridging or leaflet thickening (11 patients) had significantly longer disease duration (28.1 versus 17.7 years) and higher incidence of aortic root echo-density (82 versus 36 percent) than the remaining patients. It is concluded that a significant portion of patients with ankylosing spondylitis or Reiter's syndrome have echocardiographic evidence of aortic root involvement prior to the clinical onset of aortic regurgitation.
在一组36例类风湿变异疾病患者中，描述了二维超声心动图显示的主动脉瓣下纤维嵴、主动脉瓣叶增厚以及主动脉根部扩张和增厚的情况。该组包括25例强直性脊柱炎患者、9例赖特综合征患者以及2例炎症性肠病合并脊柱炎患者。没有患者有主动脉反流或心脏传导阻滞的临床或实验室证据。36例患者中有11例出现主动脉瓣下纤维嵴或明显的瓣叶增厚；相比之下，在29名年龄匹配的男性对照组中未发现此类变化。有主动脉瓣下纤维嵴或瓣叶增厚的患者亚组（11例患者）的病程明显更长（28.1年对17.7年），主动脉根部回声密度的发生率更高（82%对36%）。得出的结论是，相当一部分强直性脊柱炎或赖特综合征患者在主动脉反流临床发作之前就有主动脉根部受累的超声心动图证据。
