DiPiro J T, Hamilton R G, Howdieshell T R, Adkinson N F, Mansberger A R
University of Georgia College of Pharmacy, Athens.
Ann Surg. 1992 May;215(5):460-5; discussion 465-6. doi: 10.1097/00000658-199205000-00008.
Gamma E immunoglobulin (IgE) is associated with allergic reactions, but has not been described as being activated after trauma or sepsis. Total plasma IgE concentrations were determined in 32 patients with major traumatic injury, 29 patients undergoing elective abdominal operations, and 30 healthy volunteers. Mean total IgE concentrations were 271.7 ng/mL, 52.3 ng/mL, and 41.3 ng/mL, respectively (p less than 0.01 for each comparison with the trauma group). Total IgE concentrations in trauma patients at the time of admission were not significantly different from elective surgical controls, and tended to increase during the intensive care unit stay. In the trauma group, total IgE concentration was significantly greater in the 18 patients that developed sepsis syndrome compared with those that did not (p = 0.034). These data suggest that allergic mechanisms may be involved in the physiologic response to major traumatic injury and sepsis syndrome, or that other cells known to be involved in the immune responses to trauma and sepsis (macrophages, platelets, and B lymphocytes) may become activated by IgE-dependent mechanisms.
γE免疫球蛋白（IgE）与过敏反应相关，但尚未有在创伤或脓毒症后被激活的相关描述。测定了32例严重创伤患者、29例接受择期腹部手术的患者以及30名健康志愿者的血浆总IgE浓度。平均总IgE浓度分别为271.7 ng/mL、52.3 ng/mL和41.3 ng/mL（与创伤组的每次比较p均小于0.01）。创伤患者入院时的总IgE浓度与择期手术对照组无显著差异，且在重症监护病房住院期间有升高趋势。在创伤组中，发生脓毒症综合征的18例患者的总IgE浓度显著高于未发生脓毒症综合征的患者（p = 0.034）。这些数据表明，过敏机制可能参与了对严重创伤和脓毒症综合征的生理反应，或者已知参与创伤和脓毒症免疫反应的其他细胞（巨噬细胞、血小板和B淋巴细胞）可能通过IgE依赖机制被激活。
