Aggleton J P, Kentridge R W, Sembi S
Department of Psychology, University of Durham, UK.
Behav Brain Res. 1992 Jun 8;48(2):103-12. doi: 10.1016/s0166-4328(05)80146-9.
Rats with lesions in either the fornix, the amygdala, or both were compared with control animals on the acquisition of three different concurrent object discrimination tasks. In the first task the animals received one trial per day on each of six pairs of stimulus objects ('spaced' condition). In the second task the animals received four trials per day on each of six stimulus pairs ('standard' condition), and in the last task the animals received 36 trials on each of two stimulus pairs in just a single day ('massed' condition). Animals with fornical lesions were impaired on all three conditions. In contrast, the amygdala lesions only affected the 'massed' condition and then only when the animals had to select the 'non-preferred' stimulus. Although animals with combined amygdala and fornical lesions were impaired on all three conditions there was no evidence that their deficit was greater than that in the animals with lesions restricted to just the fornix. In view of the evidence that concurrent discrimination learning offers an appropriate test for anterograde amnesia these findings are seen as consistent with the notion that the hippocampus, but not the amygdala, is critically involved in the mnemonic processes disrupted by amnesia.
将穹窿、杏仁核或两者都有损伤的大鼠与对照动物在三种不同的同时进行的物体辨别任务的习得方面进行了比较。在第一个任务中，动物每天对六对刺激物体中的每一对接受一次试验（“间隔”条件）。在第二个任务中，动物每天对六对刺激物体中的每一对接受四次试验（“标准”条件），而在最后一个任务中，动物在仅仅一天内对两对刺激物体中的每一对接受36次试验（“集中”条件）。穹窿损伤的动物在所有三种条件下都受损。相比之下，杏仁核损伤仅影响“集中”条件，而且只有当动物必须选择“非偏好”刺激时才会如此。尽管杏仁核和穹窿联合损伤的动物在所有三种条件下都受损，但没有证据表明它们的缺陷比仅穹窿有损伤的动物更大。鉴于有证据表明同时辨别学习为顺行性遗忘提供了一种合适的测试，这些发现被视为与如下观点一致，即海马体而非杏仁核在被遗忘症破坏的记忆过程中起关键作用。
