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在枯草芽孢杆菌中，分解代谢控制蛋白CcpA对sigL表达的调控涉及一种阻碍机制：碳代谢与氮代谢之间的潜在联系。

Regulation of sigL expression by the catabolite control protein CcpA involves a roadblock mechanism in Bacillus subtilis: potential connection between carbon and nitrogen metabolism.

作者信息

Choi Soo-Keun, Saier Milton H

机构信息

Division of Biological Sciences, University of California at San Diego, La Jolla, CA 92093-0116, USA.

出版信息

J Bacteriol. 2005 Oct;187(19):6856-61. doi: 10.1128/JB.187.19.6856-6861.2005.

DOI:10.1128/JB.187.19.6856-6861.2005
PMID:16166551
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1251575/
Abstract

A catabolite-responsive element (CRE), a binding site for the CcpA transcription factor, was identified within the sigL structural gene encoding sigma(L) in Bacillus subtilis. We show that CcpA binds to this CRE to regulate sigL expression by a "roadblock" mechanism and that this mechanism in part accounts for catabolite repression of sigma(L)-directed levD operon expression.

摘要

在枯草芽孢杆菌中，编码σ因子（L）的sigL结构基因内发现了一种分解代谢物反应元件（CRE），它是CcpA转录因子的结合位点。我们发现，CcpA通过一种“路障”机制与该CRE结合，从而调控sigL的表达，并且这种机制在一定程度上解释了分解代谢物对由σ因子（L）指导的levD操纵子表达的阻遏作用。

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本文引用的文献

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Mol Microbiol. 2004 Mar;51(5):1471-81. doi: 10.1111/j.1365-2958.2003.03926.x.
2
The regulatory link between carbon and nitrogen metabolism in Bacillus subtilis: regulation of the gltAB operon by the catabolite control protein CcpA.枯草芽孢杆菌中碳代谢与氮代谢之间的调控联系：分解代谢物控制蛋白CcpA对gltAB操纵子的调控
Microbiology (Reading). 2003 Oct;149(Pt 10):3001-3009. doi: 10.1099/mic.0.26479-0.
3
Transcription through the roadblocks: the role of RNA polymerase cooperation.突破障碍进行转录：RNA聚合酶协作的作用
EMBO J. 2003 Sep 15;22(18):4719-27. doi: 10.1093/emboj/cdg452.
4
Nitrogen assimilation and global regulation in Escherichia coli.大肠杆菌中的氮同化与全局调控
Annu Rev Microbiol. 2003;57:155-76. doi: 10.1146/annurev.micro.57.030502.090820. Epub 2003 May 1.
5
Insufficient expression of the ilv-leu operon encoding enzymes of branched-chain amino acid biosynthesis limits growth of a Bacillus subtilis ccpA mutant.编码支链氨基酸生物合成酶的ilv-leu操纵子表达不足限制了枯草芽孢杆菌ccpA突变体的生长。
J Bacteriol. 2002 Sep;184(18):5174-8. doi: 10.1128/JB.184.18.5174-5178.2002.
6
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7
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