在枯草芽孢杆菌中，分解代谢控制蛋白CcpA对sigL表达的调控涉及一种阻碍机制：碳代谢与氮代谢之间的潜在联系。
Regulation of sigL expression by the catabolite control protein CcpA involves a roadblock mechanism in Bacillus subtilis: potential connection between carbon and nitrogen metabolism.
作者信息
Choi Soo-Keun, Saier Milton H
机构信息
Division of Biological Sciences, University of California at San Diego, La Jolla, CA 92093-0116, USA.
出版信息
J Bacteriol. 2005 Oct;187(19):6856-61. doi: 10.1128/JB.187.19.6856-6861.2005.
Abstract
A catabolite-responsive element (CRE), a binding site for the CcpA transcription factor, was identified within the sigL structural gene encoding sigma(L) in Bacillus subtilis. We show that CcpA binds to this CRE to regulate sigL expression by a "roadblock" mechanism and that this mechanism in part accounts for catabolite repression of sigma(L)-directed levD operon expression.
摘要
在枯草芽孢杆菌中，编码σ因子（L）的sigL结构基因内发现了一种分解代谢物反应元件（CRE），它是CcpA转录因子的结合位点。我们发现，CcpA通过一种“路障”机制与该CRE结合，从而调控sigL的表达，并且这种机制在一定程度上解释了分解代谢物对由σ因子（L）指导的levD操纵子表达的阻遏作用。
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