Zhao Zeng-qiang, Yu Pei-wu, Zhao Yong-liang, Shi Yan
Department of General Surgery, Southwest Hospital, The Third Military Medical University, Chongqing 400038, China.
Zhonghua Wei Chang Wai Ke Za Zhi. 2005 Jul;8(4):352-5.
To investigate the expressions of RhoC, CD44v6 and ICAM-1 in gastric cancer and their correlations.
SABC immunohistochemistry was used to detect the expressions of RhoC, CD44v6 and ICAM-1 in the specimens from 40 cases with gastric cancer. Their correlations were reviewed by clinicopathological data.
The expression of RhoC, CD44v6 and ICAM-1 were not correlated with tumor differentiation and invasion depth (P> 0.05), but significantly correlated with lymph metastasis and pTNM stage (P< 0.05). There was a significant correlation between the expression of RhoC and the expression of CD44v6 or ICAM-1 (r=0.355, P=0.006; r=0.354, P=0.003) respectively. If RhoC was positive-expressed, and either of CD44v6 or ICAM-1 was positive-expressed, the sensitivity and the specificity for predicting the lymphatic metastasis was 93.75%, 62.5% respectively.
The positive expressions of RhoC, CD44v6 and ICAM-1 are useful biological markers for predicting the metastatic potential of gastric cancer. The combined detection of three markers is a useful method for predicting lymphatic metastasis of gastric cancer.
探讨RhoC、CD44v6和ICAM-1在胃癌中的表达及其相关性。
采用SABC免疫组织化学法检测40例胃癌标本中RhoC、CD44v6和ICAM-1的表达，并结合临床病理资料分析其相关性。
RhoC、CD44v6和ICAM-1的表达与肿瘤分化程度和浸润深度无关（P>0.05），但与淋巴结转移及pTNM分期显著相关（P<0.05）。RhoC的表达与CD44v6或ICAM-1的表达分别具有显著相关性（r=0.355，P=0.006；r=0.354，P=0.003）。若RhoC呈阳性表达，且CD44v6或ICAM-1中有一个呈阳性表达，则预测淋巴结转移的敏感性和特异性分别为93.75%、62.5%。
RhoC、CD44v6和ICAM-1的阳性表达是预测胃癌转移潜能的有用生物学标志物。联合检测这三种标志物是预测胃癌淋巴结转移的一种有用方法。
