Atkinson Janette, Braddick Oliver, Rose Fredric E, Searcy Yvonne M, Wattam-Bell John, Bellugi Ursula
Visual Development Unit, Department of Psychology, University College London, Gower Street, London WC1E 6BT, UK.
Neuropsychologia. 2006;44(5):828-33. doi: 10.1016/j.neuropsychologia.2005.08.002. Epub 2005 Sep 15.
Previous studies of children with Williams syndrome (WS) have found a specific deficit in dorsal cortical stream function, indicated by poor performance in coherence thresholds for motion compared to form. Here we investigated whether this is a transient developmental feature or a persisting aspect of cerebral organization in WS. Motion and form coherence thresholds were tested in a group of 45 WS individuals aged 16-42 years, and 19 normal adult controls. Although there was considerable variation in the coherence thresholds across individuals with WS, the WS group showed overall worse performance than controls. A significant group x threshold condition interaction showed a substantially greater performance deficit for motion than for form coherence in the WS group relative to controls. This result suggests that the motion deficit is an enduring feature in WS and is a marker for one aspect of dorsal-stream vulnerability.
先前对威廉姆斯综合征（WS）患儿的研究发现，背侧皮质流功能存在特定缺陷，与形状相比，运动连贯性阈值表现较差即表明了这一点。在此，我们研究了这是一种短暂的发育特征还是WS大脑组织的持续特征。对一组年龄在16至42岁的45名WS个体和19名正常成人对照组进行了运动和形状连贯性阈值测试。尽管WS个体的连贯性阈值存在相当大的差异，但WS组的总体表现比对照组差。显著的组×阈值条件交互作用表明，相对于对照组，WS组在运动方面的表现缺陷比形状连贯性方面大得多。这一结果表明，运动缺陷是WS的一个持久特征，是背侧流易损性一个方面的标志。
