Walther Michael, Tongren Jon Eric, Andrews Laura, Korbel Daniel, King Elizabeth, Fletcher Helen, Andersen Rikke F, Bejon Philip, Thompson Fiona, Dunachie Susanna J, Edele Fanny, de Souza J Brian, Sinden Robert E, Gilbert Sarah C, Riley Eleanor M, Hill Adrian V S
Center for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Churchill Hospital, Oxford OX3 7LJ, United Kingdom.
Immunity. 2005 Sep;23(3):287-96. doi: 10.1016/j.immuni.2005.08.006.
Understanding the regulation of immune responses is central for control of autoimmune and infectious disease. In murine models of autoimmunity and chronic inflammatory disease, potent regulatory T lymphocytes have recently been characterized. Despite an explosion of interest in these cells, their relevance to human disease has been uncertain. In a longitudinal study of malaria sporozoite infection via the natural route, we provide evidence that regulatory T cells have modifying effects on blood-stage infection in vivo in humans. Cells with the characteristics of regulatory T cells are rapidly induced following blood-stage infection and are associated with a burst of TGF-beta production, decreased proinflammatory cytokine production, and decreased antigen-specific immune responses. Both the production of TGF-beta and the presence of CD4+CD25+FOXP3+ regulatory T cells are associated with higher rates of parasite growth in vivo. P. falciparum-mediated induction of regulatory T cells may represent a parasite-specific virulence factor.
了解免疫反应的调节对于控制自身免疫性疾病和传染病至关重要。在自身免疫和慢性炎症性疾病的小鼠模型中，最近已鉴定出强效调节性T淋巴细胞。尽管人们对这些细胞的兴趣激增，但其与人类疾病的相关性仍不确定。在一项通过自然途径进行疟原虫感染的纵向研究中，我们提供证据表明调节性T细胞对人类体内血期感染具有调节作用。血期感染后迅速诱导出具有调节性T细胞特征的细胞，这些细胞与转化生长因子-β（TGF-β）的大量产生、促炎细胞因子产生的减少以及抗原特异性免疫反应的降低有关。TGF-β的产生和CD4+CD25+FOXP3+调节性T细胞的存在均与体内寄生虫生长率较高有关。恶性疟原虫介导的调节性T细胞诱导可能代表一种寄生虫特异性毒力因子。
