Wensvoort G, de Kluyver E P, Luijtze E A, den Besten A, Harris L, Collins J E, Christianson W T, Chladek D
Department of Virology, Central Veterinary Institute, Lelystad, The Netherlands.
J Vet Diagn Invest. 1992 Apr;4(2):134-8. doi: 10.1177/104063879200400203.
This study reports the antigenic relatedness of isolates of Lelystad virus collected in the Netherlands, Germany, and the United States. The binding of antibodies directed against these isolates was tested in a set of field sera collected during outbreaks of porcine epidemic abortion and respiratory syndrome in Europe and outbreaks of swine infertility and respiratory syndrome (SIRS) in North America. Two sets of sera from pigs experimentally infected with Lelystad virus or SIRS virus were also tested. Although all 7 isolates reacted with anti-Lelystad virus sera, antigenic variation was considerable. The 4 European isolates resembled each other closely, but differed from the American isolates, and the 3 American isolates differed antigenically from each other. To reliably diagnose Lelystad virus infection, a common antigen must first be identified.
本研究报告了在荷兰、德国和美国收集的莱利斯塔德病毒分离株的抗原相关性。针对这些分离株的抗体结合情况，在欧洲猪流行性流产和呼吸道综合征疫情期间以及北美猪不育和呼吸道综合征（SIRS）疫情期间收集的一组现场血清中进行了检测。还检测了两组经莱利斯塔德病毒或SIRS病毒实验感染的猪的血清。尽管所有7个分离株均与抗莱利斯塔德病毒血清发生反应，但抗原变异相当大。4个欧洲分离株彼此非常相似，但与美国分离株不同，且3个美国分离株在抗原性上也彼此不同。为了可靠地诊断莱利斯塔德病毒感染，必须首先鉴定出一种共同抗原。
Zotero 插件