由胞壁酰二肽的新型去Muramyl酰基假肽类似物诱导的巨噬细胞细胞毒性因子的分泌。
Secretion of macrophage cytotoxic factors induced by new desmuramyl acylpseudopeptide analogs of muramyl dipeptide.
作者信息
Breton P, Petit C, Bousser M T, Monsigny M, Mayer R, Roche A C
机构信息
Département de Biochimie des Glycoconjugués et Lectines Endogènes, CNRS, Orléans, France.
出版信息
Oncol Res. 1992;4(3):103-7.
Sixteen desmuramyl analogs of muramyl dipeptide (MDP) were tested for their abilities to stimulate cytotoxic factor secretion by mouse peritoneal macrophages. Among them, the pseudohexapeptide Boc-Gly psi [CH2O]-D-Ala-Ala-D-Glu[Lys(H-Gly)NHEt]-NH2 appeared to be four times more effective than MDP. From this study, the D configuration of the pseudo-alanyl (or lactyl) residue appears to be essential for activity.
对十六种muramyl二肽（MDP）的去muramyl类似物进行了测试，以检测它们刺激小鼠腹腔巨噬细胞分泌细胞毒性因子的能力。其中，假六肽Boc-Gly ψ [CH2O]-D-Ala-Ala-D-Glu[Lys(H-Gly)NHEt]-NH2的效力似乎是MDP的四倍。从这项研究来看，假丙氨酰（或乳酰）残基的D构型似乎对活性至关重要。
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