Pratt D E, Vignovic E, Holt J A, Schumacher G F
Department of Obstetrics and Gynecology, Pritkzer School of Medicine, University of Chicago, Illinois.
J Assist Reprod Genet. 1992 Feb;9(1):14-8. doi: 10.1007/BF01204108.
During the normal menstrual cycle the volume of cervicovaginal fluid (CVF), as determined by the patient at home using a simple volumetric aspirating pipette, increases significantly over several days prior to the luteinizing hormone (LH) surge and decreases characteristically shortly after ovulation. The present study was undertaken to test the hypothesis that self-determined measurements of CVF volume would correlate positively with serum estradiol (E2) levels and with total follicular volume (TFV) in cycles stimulated with exogenous gonadotropins. Consequently, 20 infertility patients, undergoing human menopausal gonadotropin (hMG)-stimulated cycles, were asked to measure daily CVF. Routine serum E2 determinations and vaginal follicular ultrasound studies were performed up to and including the day of human chorionic gonadotropin (hCG) administration (designated day 0). The mean daily CVF volume (+/- SD) increased from 0.1 +/- 0.01 ml on day -6 to 0.7 +/- 0.40 ml on day -1 and then decreased to 0.6 +/- 0.40 ml on day 0. On day 0, 7 of 20 cycles (35%) demonstrated a decrease in CVF, which ranged from 0.1 to 1.0 ml (mean, 0.42 ml). The mean daily CVF correlated positively (correlation coefficient = r) with the mean daily serum E2 (r = 0.89) and with the mean daily TFV (r = 0.88). The mean daily correlation of TFV for E2 was r = 0.98. The correlation between CVF and E2 of individuals ranged from r = 0.38 to r = 0.99 and the correlation between CVF and TFV ranged from r = 0.12 to r = 1.0, while the individual correlations of E2 to TFV ranged from r = 0.60 to r = 0.99.(ABSTRACT TRUNCATED AT 250 WORDS)
在正常月经周期中，患者在家使用简单的容量抽吸移液管测定的宫颈阴道液（CVF）量，在促黄体生成素（LH）峰前数天显著增加，并在排卵后不久典型性减少。本研究旨在检验这一假设：在使用外源性促性腺激素刺激的周期中，自我测定的CVF量与血清雌二醇（E2）水平及总卵泡体积（TFV）呈正相关。因此，选取20例接受人绝经期促性腺激素（hMG）刺激周期的不孕症患者，要求他们每天测量CVF。直至并包括注射人绒毛膜促性腺激素（hCG）当天（指定为第0天），进行常规血清E2测定及阴道卵泡超声检查。平均每日CVF量（±标准差）从第-6天的0.1±0.01毫升增加至第-1天的0.7±0.40毫升，然后在第0天降至0.6±0.40毫升。在第0天，20个周期中有7个（35%）CVF出现减少，减少范围为0.1至1.0毫升（平均0.42毫升）。平均每日CVF与平均每日血清E2（相关系数 = r）及平均每日TFV（r = 0.88）呈正相关。TFV与E2的平均每日相关性为r = 0.98。个体的CVF与E2之间的相关性范围为r = 0.38至r = 0.99，CVF与TFV之间的相关性范围为r = 0.12至r = 1.0，而E2与TFV的个体相关性范围为r = 0.60至r = 0.99。（摘要截短至250字）
