Sjögren A, Sjöblom P, Hamberger L
Department of Obstetrics and Gynaecology, University of Göteborg, Sahlgrenska University Hospital, Sweden.
J Assist Reprod Genet. 1992 Feb;9(1):41-4. doi: 10.1007/BF01204113.
The rate of blastocyst development was studied in cultures of human fertilized eggs. A total of 195 spare embryos from 86 cycles in 73 in vitro fertilization (IVF) patients resulted in a total of 77 expanded blastocysts, corresponding to an overall blastocyst development of 39%. In the group of patients where pregnancy occurred, at least one of the spare embryos developed into the blastocyst stage in 100% of the patients, while the corresponding figure for nonpregnant patients was 53%. Superficially these results seem to indicate that blastocyst development could be of decisive importance for the success rate in IVF. A detailed analysis revealed, however, that this is not the case as long as in vitro culture before replacement is limited to 2-3 days.
在人类受精卵培养中研究了囊胚发育率。73例体外受精（IVF）患者的86个周期中共有195个备用胚胎，共产生77个扩张囊胚，总体囊胚发育率为39%。在妊娠发生的患者组中，100%的患者至少有一个备用胚胎发育到囊胚阶段，而非妊娠患者的相应比例为53%。表面上这些结果似乎表明囊胚发育对IVF成功率可能具有决定性意义。然而，详细分析表明，只要移植前的体外培养限于2 - 3天，情况并非如此。
