Shields L E, Serafini P C, Schenken R S, Moore C M
Department of Obstetrics and Gynecology, University of Texas Health Science Center, San Antonio 78284-7836.
J Assist Reprod Genet. 1992 Feb;9(1):57-60. doi: 10.1007/BF01204116.
Chromosomal analysis was performed on products of conception from 18 patients having early pregnancy loss after assisted reproduction. Sonographic findings prior to obtaining tissue varied from gestational sacs consistent with a blighted ovum to fetal poles with cardiac activity. The mean age of the patients was 36.3 years. There were nine (50%) normal karyotypes, five (28%) autosomal trisomies, two cases of tetraploidy, one case of monosomy, and a case with two pericentric inversions. The results of this study suggest that patients undergoing assisted reproduction are not at an increased risk for chromosomal abnormalities.
对18例辅助生殖后早期妊娠丢失患者的妊娠产物进行了染色体分析。获取组织前的超声检查结果各不相同，从符合空卵妊娠囊到有心跳的胎芽。患者的平均年龄为36.3岁。有9例（50%）核型正常，5例（28%）常染色体三体，2例四倍体，1例单体，以及1例有两个臂间倒位。本研究结果表明，接受辅助生殖的患者染色体异常风险并未增加。
