Barlow P, Lejeune B, Puissant F, Englert Y, Van Rysselberge M, Degueldre M, Vekemans M, Leroy F
IVF Clinic, St Pierre Hospital, Free University of Brussels, Belgium.
Hum Reprod. 1988 Jul;3(5):671-5. doi: 10.1093/oxfordjournals.humrep.a136765.
Between March 1983 and March 1986, 108 pregnancies were obtained at the IVF clinic of St Pierre Hospital in Brussels. There were 29 chemical pregnancies (26.8%), five ectopic pregnancies (4.6%), 15 abortions (14%) and 59 ongoing pregnancies of over 20 weeks (54%). Patients who had experienced a chemical pregnancy at first trial displayed a significantly higher rate of ongoing pregnancy at their second attempt. Among the 15 cases of abortion, a chromosomal anomaly was detected in two cases and suspected in a third. Four of the five ectopic pregnancies occurred in patients with previously documented tubal pathology. The ongoing pregnancies were distributed as 44 singletons, 13 pairs of twins, one set of triplets and one set of quadruplets. The Caesarian section rates were 21 and 40% for single and multiple pregnancies, respectively. The prematurity rate was low for singletons (4.5%) but reached 46.6% in multiple pregnancies. Two minor malformations were observed and five perinatal deaths occurred; among these latter, four cases were twins. It appears that perinatal pathology is substantially higher among IVF pregnancies than in the normal population. It is clear, however, that most of this difference is accounted for by the considerably higher rate of twin pregnancy displayed by the former group.
1983年3月至1986年3月期间，布鲁塞尔圣皮埃尔医院体外受精诊所共获得108次妊娠。其中有29次生化妊娠（26.8%）、5次异位妊娠（4.6%）、15次流产（14%）以及59次持续妊娠超过20周（54%）。首次尝试时经历过生化妊娠的患者在第二次尝试时持续妊娠率显著更高。在15例流产病例中，2例检测到染色体异常，1例疑似染色体异常。5例异位妊娠中有4例发生在先前有输卵管病变记录的患者中。持续妊娠的分布情况为：44例单胎、13例双胎、1例三胞胎和1例四胞胎。单胎和多胎妊娠的剖宫产率分别为21%和40%。单胎早产率较低（4.5%），但多胎妊娠早产率达到46.6%。观察到2例轻微畸形，发生了5例围产期死亡；其中，4例为双胞胎。体外受精妊娠的围产期病理情况似乎明显高于正常人群。然而，很明显，这种差异大部分是由前一组显著更高的双胎妊娠率造成的。
