Rinneberg Herbert, Grosenick Dirk, Moesta K Thomas, Mucke Jörg, Gebauer Bernd, Stroszczynski Christian, Wabnitz Heidrun, Moeller Michael, Wassermann Bernhard, Schlag Peter M
Division of Medical Physics and Metrological Information Technology, Physikalisch-Technische Bundesanstalt, Abbestrasse 2-12, 10587 Berlin, Germany.
Technol Cancer Res Treat. 2005 Oct;4(5):483-96. doi: 10.1177/153303460500400503.
Optical mammography is one of several new techniques for breast cancer detection and characterization presently under development for clinical use that provide information other than morphologic, in particular on the biochemical and metabolic state of normal and diseased tissue. In breast tissue, scattering of red to near infrared (NIR) light dominates absorption and NIR light may penetrate several centimeters through the breast. Optical mammography avoids the use of ionizing radiation and offers the power of diffuse optical spectroscopy. However, because of strong light scattering, spatial resolution of optical mammography is generally low. The paper reviews the results of a clinical study on scanning time-domain optical mammography comprising 154 patients carrying a total of 102 carcinomas validated by histology. Ninety two of these tumors were detected in optical mammograms retrospectively and for 87 of the detected tumors optical properties and tissue parameters were derived. In addition developments on instrumentation and data analysis are covered and possible improvements of optical mammography are briefly discussed.
光学乳腺成像技术是目前正在开发用于临床的几种乳腺癌检测和特征分析新技术之一，这些技术能够提供除形态学信息之外的信息，特别是关于正常和病变组织的生化及代谢状态的信息。在乳腺组织中，红光到近红外（NIR）光的散射占主导地位，而NIR光可以穿透乳腺几厘米。光学乳腺成像技术避免了使用电离辐射，并提供了漫射光学光谱分析的能力。然而，由于强烈的光散射，光学乳腺成像技术的空间分辨率通常较低。本文回顾了一项关于扫描时域光学乳腺成像技术的临床研究结果，该研究包括154名患者，共102例经组织学证实的癌。其中92个肿瘤是在光学乳腺造影片中回顾性检测到的，并且对87个检测到的肿瘤得出了光学特性和组织参数。此外，还涵盖了仪器设备和数据分析方面的进展，并简要讨论了光学乳腺成像技术可能的改进。
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