白光时间分辨光学乳腺成像的可行性

Feasibility of white-light time-resolved optical mammography.

作者信息

Bassi Andrea, Spinelli Lorenzo, D'Andrea Cosimo, Giusto Arianna, Swartling Johannes, Pifferi Antonio, Torricelli Alessandro, Cubeddu Rinaldo

机构信息

ULTRAS-CNR-INFM and CNR-IFN, Politecnico di Milano, Dipartimento di Fisica, Piazza Leonardo da Vinci 32, 20133 Milano, Italy.

出版信息

J Biomed Opt. 2006 Sep-Oct;11(5):054035. doi: 10.1117/1.2355663.

DOI:10.1117/1.2355663

PMID:17092184

Abstract

We demonstrate the feasibility of white-light time-resolved optical mammography. The instrumentation is based on supercontinuum light generated in photonic crystal fiber and 32-channel parallel time-correlated single-photon-counting detection. Total measurement time is of the order of 10 min for typical clinical applications. Preliminary measurements performed on volunteers show the ability of the system to determine tissue constituent concentrations and structure over the entire breast area. Furthermore, measurements on a tissue-like sample demonstrate detection and characterization of inclusions.

摘要

我们展示了白光时间分辨光学乳腺成像的可行性。该仪器基于光子晶体光纤中产生的超连续谱光以及32通道并行时间相关单光子计数检测。对于典型的临床应用，总测量时间约为10分钟。对志愿者进行的初步测量表明，该系统能够在整个乳房区域确定组织成分浓度和结构。此外，对类似组织样本的测量显示了对内含物的检测和特征描述。