[Expression of extracellular matrix metalloproteinase inducer in laryngeal squamous cell carcinoma].

OBJECTIVE

To study the expression of extracellular matrix metalloproteinase inducer (EMMPRIN/CD147) in human laryngeal squamous cell carcinoma and the relationship between the expressions and the clinical features.

METHOD

The expressions of EMMPRIN were detected by the method of immunohistochemical SP in 42 specimens taken from the patients with laryngeal squamous cell carcinoma, 28 specimens from precancerous lesion and 20 specimens from normal laryngeal tissues.

RESULT

Positive expressions rates of EMMPRIN in the specimens from laryngeal squamous cell carcinoma, precancerous lesion and normal laryngeal tissues were 88.1%, 57.1% and 5.0%, the intensive expressions rates were 52.4%, 10.7% and 0%. There were significant differences among laryngeal squamous cell carcinoma, precancerous lesion and normal laryngeal tissues. In laryngeal squamous cell carcinoma, the expressions of EMMPRIN had a significant relevance to clinical phases and lymph node metastasis. The intense expressions rate in phase II-IV was much higher than that in phase I-II, while the intense expressions rate in cases with lymph node metastasis was higher than in those cases without lymph node metastasis.

CONCLUSION

The expression of EMMPRIN has relationship with the pathological type of laryngeal tumor and has relevance to clinical stage and lymph node metastasis of laryngeal carcinoma.