Feldmann Reinhold, Weglage Josef, Roth Johannes, Foell Dirk, Frosch Michael
Department of Pediatrics, University Hospital of Münster, Münster, Germany.
Ann Neurol. 2005 Oct;58(4):605-9. doi: 10.1002/ana.20626.
In contrast with other systemic rheumatic diseases in childhood, no systematic studies exist that focus on possible long-term risks for central nervous system involvement in systemic juvenile rheumatoid arthritis (SJRA). We investigated 31 children and adolescents with SJRA, aged 6 to 24 years (mean, 12.5 years; standard deviation, 4.3 years), with mean disease duration of 6.2 years (standard deviation, 3.5 years; range, 0.6-14 years) for their cognitive and fine motor abilities. We also examined 31 matched healthy control subjects. In addition, parents assessed social activities and social and emotional problems in their children. Patients and control subjects performed within normal limits of intelligence quotient, memory and learning, attention, and fine motor scores. Less social activities were reported for patients. Patients and control subjects, however, had normal social and emotional problem scores. SJRA, although a burdensome chronic disease, is not associated with cognitive impairment or increased social and emotional problems. Cognitive performance and social adjustment of young patients with SJRA are not affected by disease activity and duration.
与儿童期其他全身性风湿性疾病不同，目前尚无系统性研究聚焦于系统性幼年特发性关节炎（SJRA）中枢神经系统受累的潜在长期风险。我们调查了31名年龄在6至24岁（平均12.5岁；标准差4.3岁）的SJRA儿童和青少年，其平均病程为6.2年（标准差3.5年；范围0.6 - 14年），评估了他们的认知和精细运动能力。我们还检查了31名匹配的健康对照者。此外，家长评估了他们孩子的社交活动以及社交和情感问题。患者和对照者在智商、记忆与学习、注意力及精细运动评分的正常范围内表现。患者报告的社交活动较少。然而，患者和对照者的社交和情感问题评分正常。SJRA虽然是一种负担沉重的慢性病，但与认知障碍或社交及情感问题增加无关。SJRA年轻患者的认知表现和社会适应不受疾病活动度和病程的影响。
