Vuorento T, Mäenpää J, Huhtaniemi I
Department of Physiology, University of Turku, Finland.
Clin Endocrinol (Oxf). 1992 May;36(5):505-10. doi: 10.1111/j.1365-2265.1992.tb02253.x.
The effect of hysterectomy on ovarian endocrine function of premenopausal women was studied.
The patients collected daily salivary samples during one preoperative cycle (1), the cycle of operation (2), the subsequent period of 30 days (3) and the cycle 6 months after operation (4).
Forty-one premenopausal women (aged 33-48 years) undergoing hysterectomy were studied; their preoperative cycles served as controls. The patients were also compared with a reference group of 17 younger fertile women.
Salivary progesterone levels were measured by radioimmunoassay.
Cycle 1 was more frequently short (P less than 0.01), with short luteal phase (P less than 0.01) and low progesterone secretion (P less than 0.05), than the cycles of younger women. Cycle 2 was longer than the other cycles (P less than 0.01), due to prolonged follicular phase (P less than 0.01). Cycle 3 differed from cycle 1 by the lesser frequency of short cycles (P less than 0.01). Cycle 4 and its follicular phase were longer than those measured in cycle 1 (P less than 0.05). Of the women with normal cycle 1, 39% (P less than 0.01) presented with luteal insufficiency (LPD, low luteal progesterone secretion) or anovulation (8%) in at least one of cycles 2 to 4. The frequency of LPD or anovulation was significantly higher in cycle 3 (P less than 0.05) but not in cycle 4, compared to 1.
Acute luteal progesterone deficiency after hysterectomy in premenopausal women is common but in most cases reversible.
研究子宫切除术对绝经前女性卵巢内分泌功能的影响。
患者在术前一个周期（1）、手术周期（2）、术后30天的后续时期（3）以及术后6个月的周期（4）内每日采集唾液样本。
对41名接受子宫切除术的绝经前女性（年龄33 - 48岁）进行了研究；她们术前的周期作为对照。这些患者还与17名年轻有生育能力的女性组成的参考组进行了比较。
采用放射免疫分析法测量唾液孕酮水平。
与年轻女性的周期相比，第1周期更频繁地出现短周期（P < 0.01），黄体期短（P < 0.01），孕酮分泌低（P < 0.05）。第2周期比其他周期长（P < 0.01），原因是卵泡期延长（P < 0.01）。第3周期与第1周期的不同之处在于短周期的频率较低（P < 0.01）。第4周期及其卵泡期比第1周期测量的更长（P < 0.05）。在第1周期正常的女性中，39%（P < 0.01）在第2至4周期中的至少一个周期出现黄体功能不全（LPD，黄体期孕酮分泌低）或无排卵（8%）。与第1周期相比，第3周期LPD或无排卵的频率显著更高（P < 0.05），但第4周期没有。
绝经前女性子宫切除术后急性黄体期孕酮缺乏很常见，但在大多数情况下是可逆的。
