钯催化四组分偶联合成吡唑和异恶唑的一锅法构建
One-pot construction of pyrazoles and isoxazoles with palladium-catalyzed four-component coupling.
作者信息
Mohamed Ahmed Mohamed S, Kobayashi Kei, Mori Atsunori
机构信息
Chemical Resources Laboratory, Tokyo Institute of Technology, R1-4 4259 Nagatsuta, Yokohama 226-8503, Japan.
出版信息
Org Lett. 2005 Sep 29;7(20):4487-9. doi: 10.1021/ol051841j.
PMID:16178565
Abstract
[reaction: see text] Four-component coupling of a terminal alkyne, hydrazine (hydroxylamine), carbon monoxide, and an aryl iodide furnishes pyrazole or isoxazole derivatives in the presence of a palladium catalyst. The reaction proceeds at room temperature and an ambient pressure of carbon monoxide in an aqueous solvent system.
摘要
[反应：见正文] 在钯催化剂存在下，末端炔烃、肼（羟胺）、一氧化碳和芳基碘的四组分偶联反应可生成吡唑或异恶唑衍生物。该反应在室温及一氧化碳常压下于水性溶剂体系中进行。
Zotero 插件