法国的莱姆病：一项基于初级保健的前瞻性研究。
Lyme disease in France: a primary care-based prospective study.
作者信息
Letrilliart L, Ragon B, Hanslik T, Flahault A
机构信息
WHO Collaborating Centre for Electronic Disease Surveillance, Inserm Unit 707, Pierre et Marie Curie University, Paris, France.
出版信息
Epidemiol Infect. 2005 Oct;133(5):935-42. doi: 10.1017/S0950268805004413.
To estimate the incidence of Lyme borreliosis in France, describe its clinical presentations, and assess its potential risk factors, we conducted a nationwide prospective study in the French Sentinelles Network, consisting of 1178 general practitioners (GPs). Of these, 875 (74%), i.e. 1.6% of all French GPs, participated in the study from May 1999 to April 2000. Eighty-six cases of Lyme disease were reported and validated, of which 77 (90%) consisted of erythema migrans. At national level, the incidence was estimated at 9.4/100,000 inhabitants. Compared to the French general population, Lyme disease patients were older (P<10(-4)), more were living in rural areas (P<10(-3)), and amongst the working population, more were farmers (P<10(-3)) and fewer, salaried workers (P<0.005). Cervidae density correlated strongly with the estimated regional incidence of Lyme disease (r=0.82). Both incidence data and identified risk factors can help to target measures for its prevention and treatment.
为了估计法国莱姆病的发病率，描述其临床表现，并评估其潜在危险因素，我们在法国哨点网络开展了一项全国性前瞻性研究，该网络由1178名全科医生组成。其中，875名（74%），即占法国所有全科医生的1.6%，于1999年5月至2000年4月参与了该研究。报告并确认了86例莱姆病病例，其中77例（90%）为游走性红斑。在国家层面，发病率估计为每10万居民9.4例。与法国普通人群相比，莱姆病患者年龄更大（P<10⁻⁴），更多居住在农村地区（P<10⁻³），在劳动人口中，农民更多（P<10⁻³），而受薪工人更少（P<0.005）。鹿的密度与估计的区域莱姆病发病率密切相关（r=0.82）。发病率数据和已确定的危险因素都有助于确定其预防和治疗措施的目标。
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