Perthame Emeline, Chartier Loïc, George Jean-Claude, Varloud Marie, Ferquel Elisabeth, Choumet Valérie
Bioinformatics and Biostatistics Hub, Institut Pasteur, Université Paris Cité, Paris, France.
LYSARC, Centre Hospitalier Lyon-Sud, Pierre-Bénite Cedex, France.
Front Med (Lausanne). 2024 Jan 17;10:1296486. doi: 10.3389/fmed.2023.1296486. eCollection 2023.
Lyme borreliosis (LB) is the most common vector disease in temperate countries of the northern hemisphere. It is caused by sensu lato complex.
To study the case presentation of LB in France, we contacted about 700 physicians every year between 2003 and 2011. An anonymous questionnaire was established allowing the collection of 3,509 cases. The information collected was imported or directly entered into databases and allowed identifying variables that were validated in a multiple correspondence analysis (MCA).
Sixty percent of the cases were confirmed, 10% were probable, 13.5% doubtful, 10.2% asymptomatic seropositive and 6.3% were negative. The clinical manifestations reported were cutaneous (63%), neurological (26%), articular (7%), ocular (1.9%) and cardiac (1.3%). Almost all patients were treated. When focusing more particularly on confirmed cases, our studies confirm that children have a distinct clinical presentation from adults. There is a gender effect on clinical presentation, with females presenting more often with erythema migrans or acrodermatitis chronica atrophicans than males, while males present more often with neurological signs or arthritis than females.
This is the first time that a comprehensive study of suspected Lyme borreliosis cases has been conducted over several years in France. Although we were not able to follow the clinical course of patients after treatment, these results suggest the interest of refining the questionnaire and of following up a cohort of patients over a sufficiently long period to obtain more information on their fate according to different parameters.
莱姆病（LB）是北半球温带国家最常见的媒介传播疾病。它由狭义伯氏疏螺旋体复合群引起。
为研究法国莱姆病的病例表现，我们在2003年至2011年期间每年联系约700名医生。制定了一份匿名问卷，收集到3509例病例。收集到的信息被导入或直接录入数据库，并通过多重对应分析（MCA）确定经过验证的变量。
60%的病例得到确诊，10%为疑似病例，13.5%为可疑病例，10.2%为无症状血清阳性，6.3%为阴性。报告的临床表现有皮肤型（63%）、神经型（26%）、关节型（7%）、眼型（1.9%）和心脏型（1.3%）。几乎所有患者都接受了治疗。更特别关注确诊病例时，我们的研究证实儿童与成人有不同的临床表现。临床表现存在性别差异，女性比男性更常出现游走性红斑或慢性萎缩性肢端皮炎，而男性比女性更常出现神经症状或关节炎。
这是法国首次对疑似莱姆病病例进行多年的综合研究。尽管我们无法跟踪患者治疗后的临床病程，但这些结果表明完善问卷以及对一组患者进行足够长时间的随访以根据不同参数获取更多关于其转归信息的重要性。
