Heimer Lennart, Van Hoesen Gary W
Department of Neurosurgery and Neuroscience, University of Virginia, Box 800212, Charlottesville, VA 22908, USA.
Neurosci Biobehav Rev. 2006;30(2):126-47. doi: 10.1016/j.neubiorev.2005.06.006. Epub 2005 Sep 23.
Current dissatisfaction with the limbic system concept reflects a desire to move beyond the limbic system in efforts to explain key facets of emotional functions and motivational behavior. This review promotes an anatomical viewpoint, which originated as a result of histotechnical advances. These improvements paved the way for anatomical discoveries, which in turn led to the concepts of the ventral striatopallidal system and extended amygdala. These two systems, together with the basal nucleus of Meynert and the septum-diagonal band system, serve as output channels for an expanded version of the classic limbic lobe of Broca, which contains all non-isocortical parts of the cortical mantle together with the large laterobasal-cortical amygdaloid complex. Thus defined, the limbic lobe contains all of the major cortical (e.g. orbitofrontal, cingulate and insular cortices in addition to the hippocampal formation) and cortical-like (laterobasal-cortical amygdala) structures known to be especially important for emotional and motivational functions. In their role as output channels for the limbic lobe, the basal forebrain functional-anatomical systems contribute to the establishment of a number of cortico-subcortical circuits, which provide an important part of the anatomical substrate for the elaboration of emotional functions and adaptive behavior.
目前对边缘系统概念的不满反映出一种愿望，即超越边缘系统，努力解释情绪功能和动机行为的关键方面。本综述倡导一种解剖学观点，这一观点源于组织技术的进步。这些改进为解剖学发现铺平了道路，进而产生了腹侧纹状体苍白球系统和扩展杏仁核的概念。这两个系统，连同迈内特基底核和隔区-斜角带系统，作为扩展版经典布洛卡边缘叶的输出通道，该边缘叶包含皮质被膜的所有非等皮质部分以及大的外侧基底皮质杏仁核复合体。如此定义，边缘叶包含所有已知对情绪和动机功能特别重要的主要皮质结构（如眶额皮质、扣带回皮质和岛叶皮质，以及海马结构）和类皮质结构（外侧基底皮质杏仁核）。作为边缘叶的输出通道，基底前脑功能解剖系统有助于建立一些皮质-皮质下回路，这些回路为阐述情绪功能和适应性行为提供了解剖学基础的重要部分。
