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新型含双杂环化合物作为潜在抗流感病毒药物的合成与生物学评价

Synthesis and biological evaluation of novel bisheterocycle-containing compounds as potential anti-influenza virus agents.

作者信息

Wang Wen-Long, Yao De-Yong, Gu Min, Fan Min-Zhi, Li Jing-Ya, Xing Ya-Cheng, Nan Fa-Jun

机构信息

Chinese National Center for Drug Screening, Shanghai Institute of Materia Medica, Shanghai Institutes of Biological Sciences, Graduate School of Chinese Academy of Sciences, Chinese Academy of Sciences, 189 Guo Shou Jing Road, Shanghai 201203, China.

出版信息

Bioorg Med Chem Lett. 2005 Dec 1;15(23):5284-7. doi: 10.1016/j.bmcl.2005.08.046. Epub 2005 Sep 23.

DOI:10.1016/j.bmcl.2005.08.046
PMID:16183283
Abstract

A series of novel 4,2-bisheterocycle tandem derivatives consisting of a methyloxazole and thiazole subunit were synthesized. Many compounds were found to inhibit human influenza A virus. Several analogues exhibited moderate biological activity and could serve as leads for further optimizations for antivirus research.

摘要

合成了一系列由甲基恶唑和噻唑亚基组成的新型4,2-双杂环串联衍生物。发现许多化合物能抑制甲型人流感病毒。几种类似物表现出中等的生物活性，可作为抗病毒研究进一步优化的先导物。

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