• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

由酰氯、仲胺、溴丙酮酸乙酯和硫氰酸铵一锅法合成功能化噻唑。

A one-pot synthesis of functionalized thiazoles from acid chlorides, secondary amines, ethyl bromopyruvate, and ammonium thiocyanate.

作者信息

Yavari Issa, Hossaini Zinatossadat, Sabbaghan Maryam, Ghazanfarpour-Darjani Majid

机构信息

Chemistry Department, Tarbiat Modares University, Tehran, Iran.

出版信息

Mol Divers. 2009 Aug;13(3):295-300. doi: 10.1007/s11030-009-9114-3. Epub 2009 Feb 10.

DOI:10.1007/s11030-009-9114-3
PMID:19205915
Abstract

An efficient one-pot synthesis of ethyl 2-(4-aryl-2-dialkylamino-1,3-thiazole-5-yl)-2-oxoacetates using acid chlorides, secondary amines, ethyl bromopyruvate, and ammonium thiocyanate is described.

摘要

描述了一种使用酰氯、仲胺、溴丙酮酸乙酯和硫氰酸铵高效一锅法合成2-(4-芳基-2-二烷基氨基-1,3-噻唑-5-基)-2-氧代乙酸乙酯的方法。

相似文献

1
A one-pot synthesis of functionalized thiazoles from acid chlorides, secondary amines, ethyl bromopyruvate, and ammonium thiocyanate.由酰氯、仲胺、溴丙酮酸乙酯和硫氰酸铵一锅法合成功能化噻唑。
Mol Divers. 2009 Aug;13(3):295-300. doi: 10.1007/s11030-009-9114-3. Epub 2009 Feb 10.
2
A rapid, four-component synthesis of functionalized thiazoles.功能化噻唑的快速四组分合成。
Comb Chem High Throughput Screen. 2011 Nov;14(9):824-8. doi: 10.2174/138620711796957134.
3
Multicomponent reactions of ammonium thiocyanate, acyl chlorides, alkyl bromides, and enaminones: a facile one-pot synthesis of thiophenes.硫氰酸铵、酰氯、溴代烷和烯胺酮的多组分反应：噻吩的简便一锅法合成。
Mol Divers. 2011 Nov;15(4):911-6. doi: 10.1007/s11030-011-9322-5. Epub 2011 Jun 22.
4
Synthesis of functionalized 1,2,4-triazole-3-thiones from ammonium isothiocyanate, acid chlorides, and arylhydrazines.从异硫氰酸铵、酰氯和芳肼合成功能化的 1,2,4-三唑-3-硫酮。
Mol Divers. 2010 Nov;14(4):763-6. doi: 10.1007/s11030-009-9218-9. Epub 2010 Jan 16.
5
Solvent-free synthesis of functionalized thiazoles using multicomponent reaction of isothiocyanates.利用异硫氰酸酯的多组分反应进行功能化噻唑的无溶剂合成。
Comb Chem High Throughput Screen. 2013 Nov;16(9):758-61. doi: 10.2174/13862073113169990036.
6
ZnO-Nanorods as an Efficient Heterogeneous Catalyst for the Synthesis of Thiazole Derivatives in Water.氧化锌纳米棒作为在水中合成噻唑衍生物的高效非均相催化剂。
Comb Chem High Throughput Screen. 2017;20(4):304-309. doi: 10.2174/1386207320666170310120747.
7
Design and Solid-Phase Parallel Synthesis of 2,4,5-Trisubstituted Thiazole Derivatives via Cyclization Reaction with a Carbamimidothioate Linker.通过带有碳酰胺硫代酯 linker 的环化反应设计和固相平行合成 2,4,5-三取代噻唑衍生物。
ACS Comb Sci. 2019 Jun 10;21(6):482-488. doi: 10.1021/acscombsci.9b00039. Epub 2019 May 22.
8
Synthesis of functionalized 5-imino-2,5-dihydro-furans through the reaction of isocyanides with activated acetylenes in the presence of ethyl bromopyruvate.在溴丙酮酸乙酯存在下，通过异腈与活性乙炔反应合成官能化的5-亚氨基-2,5-二氢呋喃。
Mol Divers. 2006 Aug;10(3):479-82. doi: 10.1007/s11030-006-9034-4. Epub 2006 Sep 12.
9
Design, synthesis and biological evaluation of 4-aryl-5-aminoalkyl-thiazole-2-amines derivatives as ROCK II inhibitors.设计、合成及生物评价 4-芳基-5-氨烷基-噻唑-2-胺衍生物作为 ROCK II 抑制剂。
Bioorg Med Chem. 2020 Oct 1;28(19):115683. doi: 10.1016/j.bmc.2020.115683. Epub 2020 Aug 3.
10
An efficient silane-promoted nickel-catalyzed amination of aryl and heteroaryl chlorides.一种高效的硅烷促进的镍催化芳基和杂芳基氯化物的胺化反应。
J Org Chem. 2008 Feb 15;73(4):1429-34. doi: 10.1021/jo702219f. Epub 2008 Jan 23.

引用本文的文献

1
Facile and efficient synthesis of functionalized iminothiopyran and isothiochromen via one-pot multicomponent reactions.通过一锅多组分反应，简便高效地合成功能化的亚氨基噻喃和异硫代色烯。
Mol Divers. 2011 Feb;15(1):35-40. doi: 10.1007/s11030-010-9230-0. Epub 2010 Apr 22.

本文引用的文献

1
Design and synthesis of thiazole-5-hydroxamic acids as novel histone deacetylase inhibitors.新型组蛋白去乙酰化酶抑制剂噻唑-5-异羟肟酸的设计与合成
Bioorg Med Chem Lett. 2007 Nov 1;17(21):5995-9. doi: 10.1016/j.bmcl.2007.07.050. Epub 2007 Aug 19.
2
Efficient synthesis of alkyl 2-[2-(arylcarbonylimino)-3-aryl-4-oxo-1, 3-thiazolan-5-ylidene]-acetates.2-[2-(芳基羰基亚氨基)-3-芳基-4-氧代-1,3-噻唑烷-5-亚基]乙酸烷基酯的高效合成
Mol Divers. 2007 May;11(2):81-5. doi: 10.1007/s11030-007-9061-9. Epub 2007 Jun 22.
3
Synthesis of some novel 2,4-disubstituted thiazoles as possible antimicrobial agents.
一些新型2,4-二取代噻唑作为潜在抗菌剂的合成。
Eur J Med Chem. 2008 Feb;43(2):261-7. doi: 10.1016/j.ejmech.2007.03.014. Epub 2007 Apr 3.
4
2-Amino-5-thiazolyl motif: a novel scaffold for designing anti-inflammatory agents of diverse structures.2-氨基-噻唑基序：一种用于设计多种结构抗炎剂的新型骨架。
Eur J Med Chem. 2008 Jan;43(1):129-34. doi: 10.1016/j.ejmech.2007.02.008. Epub 2007 Mar 1.
5
Reaction between alkyl isocyanides and isopropylidene Meldrum's acid in the presence of bidentate nucleophiles.在双齿亲核试剂存在下，烷基异腈与亚异丙基丙二酸亚异丙酯之间的反应。
Mol Divers. 2007 Feb;11(1):1-5. doi: 10.1007/s11030-006-9052-2. Epub 2006 Nov 23.
6
Synthesis of functionalized 5-imino-2,5-dihydro-furans through the reaction of isocyanides with activated acetylenes in the presence of ethyl bromopyruvate.在溴丙酮酸乙酯存在下，通过异腈与活性乙炔反应合成官能化的5-亚氨基-2,5-二氢呋喃。
Mol Divers. 2006 Aug;10(3):479-82. doi: 10.1007/s11030-006-9034-4. Epub 2006 Sep 12.
7
Synthesis and biological evaluation of novel bisheterocycle-containing compounds as potential anti-influenza virus agents.新型含双杂环化合物作为潜在抗流感病毒药物的合成与生物学评价
Bioorg Med Chem Lett. 2005 Dec 1;15(23):5284-7. doi: 10.1016/j.bmcl.2005.08.046. Epub 2005 Sep 23.
8
Novel inhibitor of p38 MAP kinase as an anti-TNF-alpha drug: discovery of N-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]benzamide (TAK-715) as a potent and orally active anti-rheumatoid arthritis agent.新型p38丝裂原活化蛋白激酶抑制剂作为抗肿瘤坏死因子-α药物：N-[4-[2-乙基-4-(3-甲基苯基)-1,3-噻唑-5-基]-2-吡啶基]苯甲酰胺（TAK-715）作为一种强效口服活性抗类风湿关节炎药物的发现。
J Med Chem. 2005 Sep 22;48(19):5966-79. doi: 10.1021/jm050165o.
9
Synthesis and biological evaluation of new thiazolyl/benzothiazolyl-amides, derivatives of 4-phenyl-piperazine.新型噻唑基/苯并噻唑基酰胺（4-苯基哌嗪衍生物）的合成与生物学评价
Farmaco. 2005 Nov-Dec;60(11-12):969-73. doi: 10.1016/j.farmac.2005.06.014. Epub 2005 Jul 22.
10
Synthesis of 2,4-disubstituted thiazoles from (Z)-(2-acetoxyvinyl)phenyl-lambda3-iodanes: nucleophilic substitution of alpha-lambda3-iodanyl ketones with thioureas and thioamides.由（Z）-（2-乙酰氧基乙烯基）苯基-λ³-碘烷合成2,4-二取代噻唑：α-λ³-碘代酮与硫脲和硫代酰胺的亲核取代反应
J Org Chem. 2003 Oct 3;68(20):7887-8. doi: 10.1021/jo020759o.