恒河猴的 SIV 感染：人类 HIV 感染的合适模型。
SIV infection of rhesus macaques of Chinese origin: a suitable model for HIV infection in humans.
机构信息
The Center for Animal Experiment/ ABSL-III Laboratory, State Key Laboratory of Virology, Wuhan University School of Medicine, Wuhan, Hubei 430071, P,R, China.
出版信息
Retrovirology. 2013 Aug 15;10:89. doi: 10.1186/1742-4690-10-89.
Abstract
Simian immunodeficiency virus (SIV) infection of Indian-origin rhesus macaques (RM) has been widely used as a well-established nonhuman primate (NHP) model for HIV/AIDS research. However, there have been a growing number of studies using Chinese RM to evaluate immunopathogenesis of SIV infection. In this paper, we have for the first time reviewed and discussed the major publications related to SIV or SHIV infection of Chinese RM in the past decades. We have compared the differences in the pathogenesis of SIV infection between Chinese RM and Indian RM with regard to viral infection, immunological response, and host genetic background. Given AIDS is a disease that affects humans of diverse origins, it is of importance to study animals with different geographical background. Therefore, to examine and compare results obtained from RM models of Indian and Chinese origins should lead to further validation and improvement of these animal models for HIV/AIDS research.
摘要
猿猴免疫缺陷病毒（SIV）感染印度恒河猴（RM）已被广泛用作 HIV/AIDS 研究的成熟非人类灵长类动物（NHP）模型。然而，越来越多的研究使用中国恒河猴来评估 SIV 感染的免疫发病机制。在本文中，我们首次回顾和讨论了过去几十年中与中国恒河猴 SIV 或 SHIV 感染相关的主要出版物。我们比较了中国恒河猴和印度恒河猴 SIV 感染发病机制的差异，包括病毒感染、免疫反应和宿主遗传背景。鉴于艾滋病是一种影响不同起源人群的疾病，研究具有不同地理背景的动物具有重要意义。因此，检查和比较来自印度和中国恒河猴模型的结果，应该能够进一步验证和改进这些用于 HIV/AIDS 研究的动物模型。
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