Hedblad B, Janzon L
Department of Community Health Sciences, Lund University, Malmö General Hospital, Sweden.
Hypertension. 1992 Jul;20(1):32-7. doi: 10.1161/01.hyp.20.1.32.
The aim of this study in 341 men (aged 68 years) without history of ischemic heart disease was to study the relation between hypertension and silent ischemic-type ST segment depression during ambulatory long-term electrocardiographic recording and to assess the influence between these two variables on cardiovascular morbidity and mortality rates. Seventy-nine men (23%) demonstrated one or more episodes of silent ischemic ST segment depression. One hundred and sixty-seven men (49%) were considered to have hypertension (i.e., they had a diastolic blood pressure of 95 mm Hg or greater or were treated with antihypertensive therapy). Forty-nine (72%) of the 68 treated hypertensive subjects were classified as uncontrolled (i.e., their diastolic blood pressure was 95 mm Hg or greater). The occurrence of ischemic ST depression was higher in hypertensive men (28%) than in normotensive men (19%). The highest incidence of ischemic ST depression (41%) was observed in treated hypertensive men with inadequate blood pressure control. Cardiac event rate during a 53-month follow-up was 6.6% in hypertensive men and 4.6% in normotensive men. Uncontrolled treated hypertensive men had a higher event rate (14%) than hypertensive men overall. Hypertensive men with inadequate blood pressure control and who demonstrated ST segment depression had the highest event rate (25%).
本研究旨在对341名无缺血性心脏病病史的男性（68岁）进行动态长期心电图记录，研究高血压与无症状缺血型ST段压低之间的关系，并评估这两个变量对心血管发病率和死亡率的影响。79名男性（23%）出现了一次或多次无症状缺血性ST段压低。167名男性（49%）被认为患有高血压（即舒张压≥95 mmHg或正在接受抗高血压治疗）。在68名接受治疗的高血压患者中，49名（72%）被归类为血压控制不佳（即舒张压≥95 mmHg）。高血压男性中缺血性ST段压低的发生率（28%）高于血压正常男性（19%）。在血压控制不佳的接受治疗的高血压男性中，缺血性ST段压低的发生率最高（41%）。在53个月的随访期间，高血压男性的心脏事件发生率为6.6%，血压正常男性为4.6%。血压控制不佳的接受治疗的高血压男性的事件发生率（14%）高于总体高血压男性。血压控制不佳且出现ST段压低的高血压男性的事件发生率最高（25%）。
