Walzer Thierry, Dalod Marc, Vivier Eric, Zitvogel Laurence
1INSERM-CNRS-Univ, Centre d'Immunologie de Marseille-Luminy, Méditerranée, Campus de Luminy, case 90, 13288 Marseille cedex 09, France.
Expert Opin Biol Ther. 2005 Sep;5 Suppl 1:S49-59. doi: 10.1517/14712598.5.1.s49.
Dendritic cells (DCs) and natural killer (NK) cells play a critical role in early defences against cancer and infections. They specialise in complementary functions, including IL-12 or IFN-alpha/beta secretion and antigen presentation for the former, and IFN-gamma secretion and killing of infected or tumour cells for the latter. Both DCs and NK cells are also sensors of the immune system that have developed different, but partially overlapping, systems to identify pathology associated danger signals. Evidence of NK-DC interaction has accumulated recently. This interaction may lead to NK cell activation, DC activation, or apoptosis depending on the activation status of both cell types. Thus, the outcome of NK-DC crosstalk is likely to influence both innate and adaptive immune responses. This review addresses the molecular mechanisms under-lying the different NK-DC interactions, and their in vivo significance in anti-tumour or antimicrobial immunity. Finally, we discuss the potential clinical implications of this new field.
树突状细胞（DCs）和自然杀伤（NK）细胞在早期抵御癌症和感染中发挥着关键作用。它们具有互补功能，前者包括分泌白细胞介素-12或干扰素-α/β以及呈递抗原，后者包括分泌干扰素-γ以及杀伤被感染细胞或肿瘤细胞。DCs和NK细胞都是免疫系统的传感器，它们发展出了不同但部分重叠的系统来识别与病理相关的危险信号。最近积累了NK-DC相互作用的证据。这种相互作用可能导致NK细胞活化、DC活化或凋亡，这取决于两种细胞类型的活化状态。因此，NK-DC串扰的结果可能会影响固有免疫和适应性免疫反应。本综述探讨了不同NK-DC相互作用背后的分子机制及其在抗肿瘤或抗菌免疫中的体内意义。最后，我们讨论了这一新领域的潜在临床意义。
