酰基磷酸盐和膦酸盐对D类β-内酰胺酶的抑制作用。
Inhibition of class D beta-lactamases by acyl phosphates and phosphonates.
作者信息
Adediran S A, Nukaga Michiyoshi, Baurin Stéphane, Frère J-M, Pratt R F
机构信息
Department of Chemistry, Wesleyan University, Middletown, CT 06459, USA.
出版信息
Antimicrob Agents Chemother. 2005 Oct;49(10):4410-2. doi: 10.1128/AAC.49.10.4410-4412.2005.
Abstract
The susceptibility of typical class D beta-lactamases to inhibition by acyl phosph(on)ates has been determined. To a large degree, these class D enzymes behaved very similarly to the class A TEM beta-lactamase towards these reagents. Dibenzoyl phosphate stood out in both cases as a lead compound towards a new class of effective inhibitors.
摘要
已测定了典型D类β-内酰胺酶对酰基磷酸（膦）酸酯抑制作用的敏感性。在很大程度上，这些D类酶对这些试剂的表现与A类TEMβ-内酰胺酶非常相似。在这两种情况下，二苯甲酰磷酸均作为一类新型有效抑制剂的先导化合物脱颖而出。
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