Cross Frederick R, Siggia Eric D
The Rockefeller University, 1230 York Avenue, New York, New York, 10021, USA.
Phys Rev E Stat Nonlin Soft Matter Phys. 2005 Aug;72(2 Pt 1):021910. doi: 10.1103/PhysRevE.72.021910. Epub 2005 Aug 24.
A characteristic property of nonlinear oscillatory systems is their ability to mode lock to a periodic, external, driving signal. In an n:m mode-locked state, the driven system executes n oscillations to every m oscillations of the driving signal, with a constant phase relationship between the two oscillations. We investigate mode locking for a mathematical model of the cell cycle in budding yeast. We determine which variables are most effective in coupling an external stimulus to the cell cycle oscillator, and speculate about whether experiments are feasible and informative for this model organism.
非线性振荡系统的一个特性是它们能够锁相到一个周期性的外部驱动信号。在n:m锁相状态下，被驱动系统每执行n次振荡，驱动信号就执行m次振荡，且这两种振荡之间存在恒定的相位关系。我们研究了芽殖酵母细胞周期数学模型的锁相现象。我们确定了哪些变量在将外部刺激与细胞周期振荡器耦合方面最有效，并推测了针对这种模式生物进行实验是否可行且具有参考价值。
