Murakami Aki, Morimoto Masafumi, Adachi Shinsuke, Ishimaru Yosuke, Sugimoto Tohru
Department of Pediatrics, Kyoto Prefectural University of Medicine, Kawaramachi-Horikoji, Kamigyo, Kyoto 602-8566, Japan.
Brain Dev. 2005 Oct;27(7):527-30. doi: 10.1016/j.braindev.2004.12.004.
A 1-year-old female with acute bilateral striatal necrosis secondary to exanthema subitum associated with human herpesvirus 6 (HHV-6) infection is reported. The patient was previously healthy. She presented with progressive neurologic signs of oral dyskinesia and involuntary movements, after suffering from exanthema subitum. Initial magnetic resonance imaging (MRI) demonstrated abnormal signals in the bilateral striatal regions. In addition, the serum HHV-6 IgM class antibody level was significantly increased. The patient is thought to be the first case of HHV-6 infection related infantile bilateral striatal necrosis (IBSN).
报告了一名1岁女性，因幼儿急疹合并人疱疹病毒6型（HHV-6）感染继发急性双侧纹状体坏死。该患者此前身体健康。她在患幼儿急疹后出现了进行性神经症状，表现为口腔运动障碍和不自主运动。最初的磁共振成像（MRI）显示双侧纹状体区域信号异常。此外，血清HHV-6 IgM类抗体水平显著升高。该患者被认为是第一例与HHV-6感染相关的婴儿双侧纹状体坏死（IBSN）病例。
