卤化四烷基铵作为离子迁移谱/质谱正电喷雾电离的化学标准品。

Tetraalkylammonium halides as chemical standards for positive electrospray ionization with ion mobility spectrometry/mass spectrometry.

作者信息

Viidanoja Jyrki, Sysoev Alexey, Adamov Alexey, Kotiaho Tapio

机构信息

Department of Chemistry, P.O. Box 55, FI-00014 University of Helsinki, Finland.

出版信息

Rapid Commun Mass Spectrom. 2005;19(21):3051-5. doi: 10.1002/rcm.2172.

DOI:10.1002/rcm.2172

PMID:16200656

Abstract

Chemical standards for positive ion mode electrospray ionization ion mobility spectrometry/mass spectrometry (ESI(+)-IMS/MS) are suggested. The low clustering tendency of tetraalkylammonium halides makes them ideal chemical standards for ESI(+)-IMS/MS. A homologous series of these compounds forms a useful external standard for instrument testing and resolution calibration of an IMS instrument. Selected homologues or a mixture of tetraalkylammonium halides can be used as mobility standards in the analytical runs. Absolute and relative reduced mobilities were calculated for C2--C8, C10 and C12 tetraalkylammonium halides. Absolute reduced mobilities in nitrogen were 1.88, 1.56, 1.33, 1.15, 1.02, 0.92, 0.84, 0.73, and 0.67 cm2 V(-1) s(-1), for C2--C8, C10 and C12 tetraalkylammonium halides, respectively. Relative reduced mobilities (relative to 2,6-di-tert-butylpyridine) for the same compounds were 1.20, 1.00, 0.855, 0.743, 0.658, 0.59, 0.54, 0.47, and 0.43, respectively.

摘要

本文提出了正离子模式电喷雾电离离子淌度谱/质谱（ESI(+)-IMS/MS）的化学标准品。卤化四烷基铵的低聚集倾向使其成为ESI(+)-IMS/MS理想的化学标准品。这些化合物的同系物系列构成了用于仪器测试和IMS仪器分辨率校准的有用外标。选定的同系物或卤化四烷基铵混合物可在分析运行中用作淌度标准品。计算了C2 - C8、C10和C12卤化四烷基铵的绝对和相对折合淌度。对于C2 - C8、C10和C12卤化四烷基铵，在氮气中的绝对折合淌度分别为1.88、1.56、1.33、1.15、1.02、0.92、0.84、0.73和0.67 cm2 V(-1) s(-1)。相同化合物相对于2,6 - 二叔丁基吡啶的相对折合淌度分别为1.20、1.00、0.855、0.743、0.658、0.59、0.54、0.47和0.43。