Karayannopoulou M, Kaldrymidou E, Constantinidis T C, Dessiris A
Department of Clinical Studies, School of Veterinary Medicine, Aristotle University of Thessaloniki, St Voutyra 11, 546 27, Thessaloniki, Greece.
J Comp Pathol. 2005 Nov;133(4):246-52. doi: 10.1016/j.jcpa.2005.05.003. Epub 2005 Oct 3.
The human "Elston and Ellis grading method" was used in dogs with mammary carcinoma to examine its relation to prognosis in this species, based on a 2-year follow-up period. Of the 85 cases examined, 27(31.8%) had well-differentiated (grade I), 28 (32.9%) had moderately differentiated (grade II) and 30 (35.3%) had poorly differentiated (grade III) carcinomas. Two years after mastectomy, significant differences in survival between cases with different tumour grade were found; thus, survival was worse in dogs with grade III carcinomas than in those with grade II (P<0.05) or grade I (P<0.001) tumours. However, in dogs with simple carcinomas which had a less favourable prognosis than that of other carcinomas (P<0.001), there was no significant difference in survival between grade II and grade III cases (P=0.878), both having a very poor prognosis. Undifferentiated (grade III) carcinoma cases had a 21-fold increased risk of death as compared with differentiated (grade I and II) carcinoma cases. An increased risk (about 10-fold) was also associated with undifferentiated simple carcinomas as compared with differentiated ones. The predictive value of histological grade was not influenced by tumour size or age of the dog at mastectomy; nodal metastasis, however, worsened the prognosis (P<0.001). Routine use of this human grading method would help the clinician to make a more accurate prognosis in the interests of post-surgical management in dogs with mammary carcinomas.
基于2年的随访期,采用人类的“埃尔森和埃利斯分级法”对患有乳腺癌的犬进行检查,以研究其与该物种预后的关系。在检查的85例病例中,27例(31.8%)为高分化(I级),28例(32.9%)为中分化(II级),30例(35.3%)为低分化(III级)癌。乳房切除术后两年,发现不同肿瘤分级的病例在生存率上存在显著差异;因此,III级癌犬的生存率低于II级(P<0.05)或I级(P<0.001)肿瘤犬。然而,在预后比其他癌更差的单纯癌犬中(P<0.001),II级和III级病例的生存率没有显著差异(P=0.878),两者预后都很差。与分化型(I级和II级)癌病例相比,未分化(III级)癌病例的死亡风险增加了21倍。与分化型单纯癌相比,未分化单纯癌的风险也增加(约10倍)。组织学分级的预测价值不受肿瘤大小或乳房切除时犬的年龄影响;然而,淋巴结转移会使预后恶化(P<0.001)。常规使用这种人类分级方法将有助于临床医生为患有乳腺癌的犬进行更准确的预后评估,以利于术后管理。