Purzyc L, Pielichowski J, Kwiatkowska J, Bogusławska-Jaworska J
Arch Immunol Ther Exp (Warsz). 1979;27(6):861-6.
In erythrocytes of children with the acute lymphoblastic leukemia the rise in total phospholipid content, confined predominantly to lecithin, the decrease of cholesterol/phospholipid ratio and the increase of the Mg++-activated ATP-ase activity was found prior to treatment. The abnormalities of the lipid composition were in general persistent also in remission. The activity of erythrocytes ATP-ase decreased to normal values after achievement of the reversion of clinical and hematological symptoms of the disease. The increase of the enzyme activity may be induced by the in vitro incubation of normal erythrocyte with the blood plasma of patients in the acute stage of lymphoblastic leukemia but not in remission.
在急性淋巴细胞白血病患儿的红细胞中，治疗前发现总磷脂含量升高，主要局限于卵磷脂，胆固醇/磷脂比值降低，Mg++激活的ATP酶活性增加。脂质组成的异常在缓解期通常也持续存在。疾病的临床和血液学症状恢复后，红细胞ATP酶活性降至正常值。酶活性的增加可通过将正常红细胞与淋巴细胞白血病急性期而非缓解期患者的血浆进行体外孵育来诱导。
