Boudou Caroline, Balosso Jacques, Estève François, Elleaume Hélène
INSERM-U647/ESRF European Synchrotron Radiation Facility, BP 220, 38043 Grenoble Cedex 9, France.
Phys Med Biol. 2005 Oct 21;50(20):4841-51. doi: 10.1088/0031-9155/50/20/007. Epub 2005 Oct 4.
A radiation dose enhancement can be obtained in brain tumours after infusion of an iodinated contrast agent and irradiation with kilovoltage x-rays in tomography mode. The aim of this study was to assess dosimetric properties of the synchrotron stereotactic radiotherapy technique applied to humans (SSR) for preparing clinical trials. We designed an interface for dose computation based on a Monte Carlo code (MCNPX). A patient head was constructed from computed tomography (CT) data and a tumour volume was modelled. Dose distributions were calculated in SSR configuration for various energy beam and iodine content in the target volume. From the calculations, it appears that the iodine-filled target (10 mg ml(-1)) can be efficiently irradiated by a monochromatic beam of energy ranging from 50 to 85 keV. This paper demonstrates the feasibility of stereotactic radiotherapy for treating deep-seated brain tumours with monoenergetic x-rays from a synchrotron.
在注入碘化造影剂并在断层扫描模式下用千伏级X射线照射后，脑肿瘤中可获得辐射剂量增强。本研究的目的是评估应用于人体的同步加速器立体定向放射治疗技术（SSR）的剂量学特性，以准备临床试验。我们基于蒙特卡罗代码（MCNPX）设计了一个剂量计算界面。根据计算机断层扫描（CT）数据构建患者头部，并对肿瘤体积进行建模。针对不同能量束和靶体积中的碘含量，在SSR配置下计算剂量分布。从计算结果来看，能量范围为50至85 keV的单色束可有效照射充满碘的靶区（10 mg ml(-1)）。本文证明了利用同步加速器产生的单能X射线进行立体定向放射治疗深部脑肿瘤的可行性。
