Harpur A G, Andres A C, Ziemiecki A, Aston R R, Wilks A F
Melbourne Tumor Biology Branch, Ludwig Institute for Cancer Research, Victoria, Australia.
Oncogene. 1992 Jul;7(7):1347-53.
We have isolated cDNA clones encoding a third, widely expressed, member of the JAK family of protein tyrosine kinases (PTKs). The anticipated amino acid sequence of JAK2 predicts the presence of two kinase-related domains, a feature characteristic of this family of PTKs. The structural similarity of JAK2 to the other members of this family extends towards their N-termini, beyond the two kinase-related domains, and reveals five further domains of substantial amino acid similarity. The C-terminal portion of one of these domains, the JH4 domain, bears an intriguing, albeit tenuous, similarity to the core element of the SH2 domain, whereas the remaining JAK homology domains do not appear to be a feature of other known proteins.
我们已经分离出编码蛋白酪氨酸激酶（PTK）JAK家族第三个广泛表达成员的cDNA克隆。JAK2的预期氨基酸序列预测存在两个激酶相关结构域，这是该PTK家族的一个特征。JAK2与该家族其他成员的结构相似性延伸至其N端，超出了两个激酶相关结构域，并揭示了另外五个氨基酸序列有显著相似性的结构域。其中一个结构域JH4的C端部分与SH2结构域的核心元件存在有趣的相似性，尽管这种相似性很微弱，而其余的JAK同源结构域似乎不是其他已知蛋白质的特征。
