作为直接不对称羟醛反应模块化催化剂的小肽：具有醛缩酶活性的古老肽
Small peptides as modular catalysts for the direct asymmetric aldol reaction: ancient peptides with aldolase enzyme activity.
作者信息
Zou Weibiao, Ibrahem Ismail, Dziedzic Pawel, Sundén Henrik, Córdova Armando
机构信息
Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, Sweden.
出版信息
Chem Commun (Camb). 2005 Oct 21(39):4946-8. doi: 10.1039/b509920j. Epub 2005 Sep 7.
DOI:10.1039/b509920j
PMID:16205809
Abstract
Simple peptides and their analogues having a primary amino group as the catalytic residue mediate the direct asymmetric intermolecular aldol reaction with high stereoselectivity and furnish the corresponding aldol products with up to 99% ee; this intrinsic ability of highly modular peptides may explain the initial molecular evolution of aldolase enzymes.
摘要
具有伯氨基作为催化残基的简单肽及其类似物介导直接不对称分子间羟醛反应，具有高立体选择性，并提供对映体过量高达99%的相应羟醛产物；高度模块化肽的这种内在能力可能解释了醛缩酶的最初分子进化。
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