Farah M H, Samuelsson G
Department of Pharmacognosy, Uppsala University, Sweden.
Planta Med. 1992 Feb;58(1):14-8. doi: 10.1055/s-2006-961380.
Coniferaldehyde, scopoletin, sinapaldehyde, and syringaldehyde were isolated from an aqueous extract of Senra incana. All four compounds inhibited prostaglandin synthetase in a dose-dependent way. Compared to aspirin, the potency of coniferaldehyde and scopoletin was about five times higher, whereas syringaldehyde and sinapaldehyde had about half the potency of this reference compound. On topical application, sinapaldehyde and scopoletin dose-dependently inhibited ethyl phenylpropiolate-induced edema of the rat ear. The active dose range was 1-10 micrograms/ear. Higher doses had a lower effect. Syringaldehyde was active in the range 20-100 micrograms/ear, whereas the effect of coniferaldehyde was inconclusive. Coniferaldehyde and sinapaldehyde inhibited electrically induced contractions of the guinea pig ileum in a dose-dependent way. Syringaldehyde showed a weak inhibition at a concentration of 550 microM.
松柏醛、东莨菪素、芥子醛和丁香醛是从灰毛紫菀的水提取物中分离得到的。所有这四种化合物均以剂量依赖性方式抑制前列腺素合成酶。与阿司匹林相比，松柏醛和东莨菪素的效力约高五倍，而丁香醛和芥子醛的效力约为该参比化合物的一半。局部应用时，芥子醛和东莨菪素剂量依赖性地抑制大鼠耳部苯丙炔酸乙酯诱导的水肿。有效剂量范围为1-10微克/耳。较高剂量的效果较低。丁香醛在20-100微克/耳范围内有活性，而松柏醛的效果尚无定论。松柏醛和芥子醛以剂量依赖性方式抑制豚鼠回肠的电诱导收缩。丁香醛在550微摩尔浓度时显示出微弱的抑制作用。
