Romieu Isabelle, Téllez-Rojo Martha Maria, Lazo Mariana, Manzano-Patiño Abigail, Cortez-Lugo Marlene, Julien Pierre, Bélanger Marie Claire, Hernandez-Avila Mauricio, Holguin Fernando
Instituto Nacional de Salud Pública, Cuernavaca, Mexico.
Am J Respir Crit Care Med. 2005 Dec 15;172(12):1534-40. doi: 10.1164/rccm.200503-372OC. Epub 2005 Oct 6.
Environmental exposure to particulate matter of 2.5 microm or less (PM2.5) has been associated with changes in heart rate variability (HRV).
To evaluate the effect of supplementation with omega-3 polyunsaturated fatty acids on the reduction of HRV associated with PM2.5 exposure.
Randomized double-blind trial.
Mexico City, Mexico.
50 nursing home residents older than 60 yr.
Randomization to either 2 g/d of fish oil versus 2 g/d of soy oil as the control, with 6 mo follow-up (1-mo presupplementation and 5-mo supplementation) or repeated HRV measurements. PM2.5 was monitored indoors and outdoors.
The association between HRV and 1 SD change in PM2.5 (8 microg/m3).
In the group receiving fish oil, the reduction in HRV-high-frequency log(10)-transformed associated with a 1-SD change in PM2.5 was -54% (95% confidence interval, -72, -24) in the presupplementation phase, and only -7% (95% confidence interval, -20,+7) in the supplementation phase (p < 0.01 for the effect of supplementation), with changes in other HRV parameters also being significantly less pronounced during supplementation. Small decreases in PM2.5-associated reductions in HRV parameters also occurred in the group receiving soy oil, but these were not significant. Fish oil supplementation was significantly better in preventing the reduction in percentage of successive normal RR intervals differing by more than 50 ms (p = 0.03) and the root square of the mean of the sum of the squares of differences between adjacent intervals (p = 0.05) than soy oil supplementation.
Supplementation with 2 g/d of fish oil prevented HRV decline related to PM2.5 exposure in the study population.
环境暴露于2.5微米及以下的颗粒物（PM2.5）与心率变异性（HRV）的变化有关。
评估补充ω-3多不饱和脂肪酸对降低与PM2.5暴露相关的HRV的效果。
随机双盲试验。
墨西哥墨西哥城。
50名60岁以上的养老院居民。
随机分为每天服用2克鱼油组和每天服用2克大豆油组作为对照，随访6个月（补充前1个月和补充5个月）或重复进行HRV测量。在室内和室外监测PM2.5。
HRV与PM2.5 1标准差变化（8微克/立方米）之间的关联。
在接受鱼油的组中，补充前阶段，与PM2.5 1标准差变化相关的HRV高频对数（10）转换值降低了-54%（95%置信区间，-72，-24），而在补充阶段仅降低了-7%（95%置信区间，-20，+7）（补充效果p<0.01），补充期间其他HRV参数的变化也明显不那么显著。接受大豆油的组中，与PM2.5相关的HRV参数降低也有小幅下降，但不显著。补充鱼油在预防连续正常RR间期差异超过50毫秒的百分比降低（p = 0.03）和相邻间期差异平方和均值的平方根降低（p = 0.05）方面明显优于补充大豆油。
在研究人群中，每天补充2克鱼油可预防与PM2.5暴露相关的HRV下降。
