Lauritzen Lotte, Christensen Jeppe H, Damsgaard Camilla T, Michaelsen Kim F
Department of Human Nutrition, University of Copenhagen, 1958 Frederiksberg C, Denmark.
Pediatr Res. 2008 Dec;64(6):610-4. doi: 10.1203/PDR.0b013e318186e5c5.
Polyunsaturated n-3 fatty acids (n-3PUFA) may improve brain development and prevent cardiovascular disease. Heart rhythm is autonomically controlled and among the affected cardiovascular risk markers in adults. The aim of the study was to examine whether fish oil supplementation in late infancy could modify heart rate (HR) and heart rate variability (HRV). In a 2 x 2-intervention, 83 healthy Danish infants were randomized to +/- fish oil (3.4 +/- 1.1 mL/d) and cow's milk or infant formula from 9 to 12 mo of age. In 57 infants, 0.5-h ECG recordings were successfully obtained before and after the intervention and erythrocyte fatty acid composition was determined in 30 of these. Fish oil supplementation raised erythrocyte n-3PUFA content (p < 0.001). No significant group differences were seen in HR or HRV. However, a fish-oil x gender interaction was observed on mean RR interval (p = 0.001) with a 6% longer mean RR interval in fish-oil-supplemented boys (p = 0.007). Irrespective of gender, there was a positive association between the 9- and 12-mo changes in RR interval and erythrocyte n-3PUFA (p < 0.001). In infants with confirmed changes in erythrocyte n-3PUFA, mean RR interval was found to be longer (p = 0.011) in the fish-oil-supplemented groups. The study suggests that fish oil may affect heart rhythm in infants similar to that observed in adults. This may imply low n-3PUFA-status in late infancy and n-3PUFA influence on CNS function.
多不饱和n-3脂肪酸（n-3PUFA）可能改善大脑发育并预防心血管疾病。心脏节律受自主神经控制，是成人心血管风险标志物之一。本研究的目的是检验婴儿晚期补充鱼油是否能改变心率（HR）和心率变异性（HRV）。在一项2×2干预研究中，83名健康丹麦婴儿被随机分为±鱼油组（3.4±1.1 mL/d），并在9至12月龄时分别给予牛奶或婴儿配方奶粉。57名婴儿在干预前后成功获得了0.5小时的心电图记录，其中30名婴儿测定了红细胞脂肪酸组成。补充鱼油提高了红细胞n-3PUFA含量（p<0.001）。HR或HRV未见显著组间差异。然而，在平均RR间期观察到鱼油×性别的交互作用（p = 0.001），补充鱼油的男孩平均RR间期长6%（p = 0.007）。无论性别如何，RR间期9至12个月的变化与红细胞n-3PUFA之间存在正相关（p<0.001）。在红细胞n-3PUFA有确认变化的婴儿中，补充鱼油组的平均RR间期更长（p = 0.011）。该研究表明，鱼油可能影响婴儿的心脏节律，类似于在成人中观察到的情况。这可能意味着婴儿晚期n-3PUFA状态较低以及n-3PUFA对中枢神经系统功能有影响。
