Saugstad Ola Didrik
Department of Pediatric Research, Rikshospitalet Faculty Division, University of Oslo, Oslo, Norway.
Biol Neonate. 2005;88(3):228-36. doi: 10.1159/000087586.
In this review the development of the concept 'hypoxia-reoxygenation injury' is outlined. An update of some important factors and mechanisms related to oxidative stress injury in newborn infants is presented, including the metabolism of glutathione, the role of antioxidants, iron and nitric oxide, and how these may influence health and disease in the newborn and contribute to 'oxygen radical disease of the newborn'. New insight into how hyperoxia and hypoxia may induce changes leading to retinopathy of prematurity by vascular endothelial growth factor acting in concert with insulin-like growth factor is briefly summarized. Inflammation and oxidative stress seem to be two sides of the same coin in newborn babies both contributing to injury partly through similar mechanisms.
本综述概述了“缺氧-复氧损伤”这一概念的发展。介绍了与新生儿氧化应激损伤相关的一些重要因素和机制的最新情况，包括谷胱甘肽的代谢、抗氧化剂、铁和一氧化氮的作用，以及这些因素如何影响新生儿的健康和疾病，并导致“新生儿氧自由基疾病”。简要总结了关于高氧和缺氧如何通过血管内皮生长因子与胰岛素样生长因子协同作用诱导导致早产儿视网膜病变的变化的新见解。炎症和氧化应激在新生儿中似乎是同一枚硬币的两面，二者都部分地通过相似机制导致损伤。
