Meneghelli Marta, Verlato Giovanna, Stocchero Matteo, Righetto Anna, Priante Elena, Zanetto Lorenzo, Pirillo Paola, Giordano Giuseppe, Baraldi Eugenio
Neonatal Intensive Care Unit, Department of Women's and Children's Health, University Hospital of Padova, 35128 Padova, Italy.
Paediatric Nutrition Service-Neonatal Intensive Care Unit, Department of Women's and Children's Health, University Hospital of Padova, 35128 Padova, Italy.
Metabolites. 2025 Aug 1;15(8):518. doi: 10.3390/metabo15080518.
Nutrition is of paramount importance during early development, since suboptimal growth in this period of life is linked to adverse long- and mid-term outcomes. This is particularly relevant for preterm infants, who fail to thrive during the first weeks of life and develop extrauterine growth restriction (EUGR). This group of premature babies represents an interesting population to investigate using a metabolomic approach to optimize nutritional intake. To analyse and compare the urinary metabolomic pattern at birth of preterm infants with and without growth restriction at 36 weeks of postmenstrual age or at discharge, searching for putative markers of growth failure. We enrolled preterm infants between 23 and 32 weeks of gestational age (GA) and/or with a birth weight <1500 g, admitted to the Neonatal Intensive Care Unit (NICU) at the Department of Women's and Children's Health of Padova University Hospital. We collected urinary samples within 48 h of life and performed untargeted metabolomic analysis using mass spectrometry. : Sixteen EUGR infants were matched with sixteen non-EUGR controls. The EUGR group showed lower levels of L-cystathionine, kynurenic acid, L-carnosine, N-acetylglutamine, xanthurenic acid, aspartylglucosamine, DL5-hydroxylysine-hydrocloride, homocitrulline, and L-aminoadipic acid, suggesting a lower anti-inflammatory and antioxidant status with respect to the non-EUGR group. Metabolomic analysis suggests a basal predisposition to growth restriction, the identification of which could be useful for tailoring nutritional approaches.
营养在早期发育过程中至关重要，因为生命这一时期的生长欠佳与不良的中长期后果相关。这对于早产儿尤为重要，他们在出生后的头几周生长不良，并出现宫外生长受限（EUGR）。这组早产婴儿是一个有趣的群体，可通过代谢组学方法进行研究以优化营养摄入。分析和比较孕龄36周或出院时有无生长受限的早产儿出生时的尿液代谢组学模式，寻找生长失败的潜在标志物。我们纳入了孕周在23至32周之间和/或出生体重<1500 g的早产儿，这些婴儿入住了帕多瓦大学医院妇女和儿童健康部的新生儿重症监护病房（NICU）。我们在出生后48小时内收集尿液样本，并使用质谱进行非靶向代谢组学分析。16名宫外生长受限婴儿与16名非宫外生长受限对照进行匹配。宫外生长受限组的L-胱硫醚、犬尿酸、L-肌肽、N-乙酰谷氨酰胺、黄尿酸、天冬氨酰葡糖胺、DL5-羟基赖氨酸盐酸盐、高瓜氨酸和L-氨基己二酸水平较低，这表明与非宫外生长受限组相比，其抗炎和抗氧化状态较低。代谢组学分析提示存在生长受限的基础易感性，对其进行识别可能有助于定制营养方案。
