Groothuis P G, Nap A W, Winterhager E, Grümmer R
Research Institute GROW, Department of Obstetrics and Gynaecology, University Hospital Maastricht, Maastricht, The Netherlands.
Angiogenesis. 2005;8(2):147-56. doi: 10.1007/s10456-005-9005-x. Epub 2005 Oct 7.
Endometriosis, defined as the presence of endometrial tissue outside the uterus, is an estrogen-dependent disease which causes pelvic pain and subfertility in women of reproductive age. The condition has a dramatic impact on the professional, social and marital life of sufferers. Direct and indirect evidence suggests that angiogenesis is required for the development and persistence of endometriosis. In this review the state-of-the-art with regard to our understanding of the role of angiogenesis in the ectopic implantation and survival of menstrual endometrial tissue will be discussed.
子宫内膜异位症被定义为子宫外存在子宫内膜组织，是一种雌激素依赖性疾病，可导致育龄女性盆腔疼痛和生育力低下。这种疾病对患者的职业、社交和婚姻生活产生巨大影响。直接和间接证据表明，血管生成是子宫内膜异位症发生和持续存在所必需的。在这篇综述中，我们将讨论关于血管生成在月经子宫内膜组织异位植入和存活中的作用的最新认识。
