Nisolle M, Alvarez M-L, Colombo M, Foidart J-M
Département de gynécologie-obstétrique, université de Liège, hôpital de la Citadelle, 1, boulevard du 12(e) de Ligne, 4000 Liège, Belgique.
Gynecol Obstet Fertil. 2007 Sep;35(9):898-903. doi: 10.1016/j.gyobfe.2007.07.021. Epub 2007 Aug 21.
Endometriosis, defined by the development of endometrial tissue outside the uterus, is a benign disease responsible for infertility and pelvic pain. The diagnosis based on a detailed gynecological history and a careful clinical examination should be done as early as possible in order to treat patients correctly. Medical treatment is not appropriate in all cases and surgical treatment should be proposed but morbidity is related to the severity of the lesion. Ectopic implantation of endometrial cells needs complex interactions between host tissue and epithelial endometrial cells. The conditions for the development of endometriosis are estrogeno-dependent growth of endometrial cells, induction of angiogenesis and lymphangiogenesis. Principal cellular and molecular factors of angiogenesis, lymphangiogenesis and fibrosis should be identified in order to develop new therapeutic strategies of endometriosis.
子宫内膜异位症是指子宫外出现子宫内膜组织，这是一种导致不孕和盆腔疼痛的良性疾病。基于详细的妇科病史和仔细的临床检查进行诊断，应尽早进行，以便正确治疗患者。并非所有病例都适合药物治疗，应考虑手术治疗，但发病率与病变严重程度相关。子宫内膜细胞的异位植入需要宿主组织与子宫内膜上皮细胞之间复杂的相互作用。子宫内膜异位症发展的条件是子宫内膜细胞的雌激素依赖性生长、血管生成和淋巴管生成的诱导。为了开发子宫内膜异位症的新治疗策略，应确定血管生成、淋巴管生成和纤维化的主要细胞和分子因素。
