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从香蜂草叶片中提取的抗疟二萜类化合物。

Antiplasmodial diterpenoid from the leaves of Hyptis suaveolens.

作者信息

Chukwujekwu J C, Smith P, Coombes P H, Mulholland D A, van Staden J

机构信息

Research Centre for Plant Growth and Development, School of Biological and Conservation Sciences, University of KwaZulu-Natal Pietermaritzburg, Private Bag X0l, Scottsville 3209, South Africa.

出版信息

J Ethnopharmacol. 2005 Nov 14;102(2):295-7. doi: 10.1016/j.jep.2005.08.018. Epub 2005 Oct 5.

DOI:10.1016/j.jep.2005.08.018
PMID:16213121
Abstract

Bioactivity-guided fractionation of the petroleum ether extract of the leaves of Hyptis suaveolens, widely used in Traditional Medicine, has led to the isolation of an abietane-type diterpenoid endoperoxide, 13 alpha-epi-dioxiabiet-8(14)-en-18-ol, displaying high antiplasmodial activity (IC(50) 0.1 microg/ml).

摘要

对传统医学中广泛使用的香蜂草叶的石油醚提取物进行生物活性导向分离,已分离出一种枞烷型二萜环氧化物,即13α-表-二氧枞-8(14)-烯-18-醇,其显示出高抗疟活性(半数抑制浓度为0.1微克/毫升)。

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