Begum Azmath Unnisa, Venkatesh Sama, Prakash Jaya, Alvala Ravi
Department of Pharmacognosy and Phytochemistry, G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad, Telangana, India.
Department of Pharmacy, Faculty, University College of Chemical Technology, Osmania University, Hyderabad, Telangana, India.
Ayu. 2016 Apr-Jun;37(2):145-150. doi: 10.4103/ayu.AYU_198_15.
Diabetes mellitus (DM) is a chronic disease characterized by high blood glucose levels due to absolute or relative circulating insulin levels. Plants represent a major potential source of drugs for treating diabetes. The study of plants having antidiabetic activity may give a new approach in the treatment of DM.
This study was aimed to investigate the glucose utilization capacity of bioactivity-guided fractions of and .
The dried coarse powdered plant material was extracted in aqueous ethanol by cold maceration; further, ethanolic extracts were fractionated using solvents of varying polarity and were investigated in isolated rat hemidiaphragm using 0.1% and 0.2% concentrations of plant extracts.
The tested fractions of both plants showed significant and dose-dependent increased glucose uptake capacity and was found to be maximum with petroleum ether and aqueous ethanolic extracts of both plants; 0.2% concentration of both plant extracts is superior in activity when compared to 0.1% of the test extracts. has produced more glucose utilization capacity when compared to .
The activity of is comparable to standard insulin ( < 0.01). Both the plant materials have some extra pancreatic mechanism like glucose uptake by peripheral tissue.
糖尿病（DM）是一种慢性病，其特征是由于循环胰岛素水平绝对或相对不足导致血糖水平升高。植物是治疗糖尿病药物的主要潜在来源。对具有抗糖尿病活性的植物进行研究可能为糖尿病的治疗提供新方法。
本研究旨在研究[植物名称1]和[植物名称2]生物活性导向组分的葡萄糖利用能力。
将干燥的粗粉植物材料用冷浸法在乙醇水溶液中提取；进一步地，用不同极性的溶剂对乙醇提取物进行分离，并使用0.1%和0.2%浓度的植物提取物在分离的大鼠半膈肌中进行研究。
两种植物的受试组分均显示出显著且剂量依赖性的葡萄糖摄取能力增加，并且发现两种植物的石油醚提取物和乙醇水提取物的葡萄糖摄取能力最强；与0.1%的受试提取物相比，两种植物提取物0.2%的浓度活性更高。与[植物名称2]相比，[植物名称1]产生了更多的葡萄糖利用能力。
[植物名称1]的活性与标准胰岛素相当（P < 0.01）。两种植物材料都有一些胰腺外机制，如外周组织对葡萄糖的摄取。
