Department of Para Clinical Sciences, The University of the West Indies, St. Augustine, Trinidad and Tobago.
Neurosci Lett. 2009 Nov 20;465(3):282-4. doi: 10.1016/j.neulet.2009.09.035. Epub 2009 Sep 19.
To investigate whether sialic acid could discriminate between healthy age matched controls and patients with dementias of the Alzheimer's type (AD), and pure vascular dementia (VaD). 27 patients and 51 controls were administered the Mini-Mental State Examination (MMSE) and had blood analyzed for levels of total sialic acid, total homocysteine (tHcy), and C-reactive protein (CRP). Significant differences were found between the mean MMSE scores for patients with dementia compared with controls. Sialic acid levels were significantly higher in patients with AD compared with controls and homocysteine levels were higher in VaD. Sialic acid levels discriminated between patients with dementia of the Alzheimer's type and healthy controls only. The MMSE could discriminate between controls and patients with dementia but not between the subtypes and homocysteine was significant for patients with VaD.
为了研究唾液酸是否可以区分健康的年龄匹配对照者和阿尔茨海默病（AD）以及单纯血管性痴呆（VaD）患者，对 27 名患者和 51 名对照者进行了简易精神状态检查（MMSE），并分析了总唾液酸、总同型半胱氨酸（tHcy）和 C 反应蛋白（CRP）的水平。与对照组相比，痴呆患者的 MMSE 评分平均值存在显著差异。与对照组相比，AD 患者的唾液酸水平明显升高，同型半胱氨酸水平在 VaD 患者中也升高。唾液酸水平仅能区分阿尔茨海默病型痴呆患者和健康对照者。MMSE 可以区分对照者和痴呆患者，但不能区分亚型，同型半胱氨酸对 VaD 患者有显著意义。
