Hildebrand J, Moussa Z, Raftopoulos C, Vanhouche J, Laute M A, Przedborski S
Neurology Service, Erasmus Hospital, Brussels, Belgium.
Acta Neurol Scand. 1992 May;85(5):340-2. doi: 10.1111/j.1600-0404.1992.tb04056.x.
We studied the nycterohemeral variations of homovanillic acid (HVA) in ventricular cerebrospinal fluid (CSF) in 24 patients undergoing monitoring of intracranial pressure as part of the normotensive hydrocephalus (NTH) work-up. CSF samples were obtained every 4 h in each patient. The mean individual values of HVA in the ventricular CSF ranged from 133 to 421 ng/ml, and they could not be correlated to any clinical feature. The intraindividual levels of HVA were stable throughout 24 hours, with a variation coefficient inferior to 10% in 63% of cases, and inferior to 20% in all the patients.
我们研究了24例接受颅内压监测的患者脑室脑脊液（CSF）中高香草酸（HVA）的昼夜变化，这些患者均作为正常压力脑积水（NTH）检查的一部分。每位患者每4小时采集一次脑脊液样本。脑室脑脊液中HVA的个体平均值在133至421 ng/ml之间，且与任何临床特征均无相关性。HVA的个体内水平在24小时内保持稳定，63%的病例变异系数低于10%，所有患者的变异系数均低于20%。
